PMID: 3768734Aug 1, 1986

Neuroanatomical mapping of hypothalamic regions mediating verapamil hyper- and hypothermia in the cat

Brain Research Bulletin
A H RezvaniR D Myers

Abstract

Guide cannulae for microinjection and push-pull perfusion in the unrestrained cat were implanted bilaterally in the anterior hypothalamic, preoptic area (AH/POA) and posterior hypothalamus (PH). Postoperatively, the region was first identified in AH/POA which was reactive to norepinephrine or in PH to excess Ca++ ions; in both cases a hypothermic response was produced. Then either an artificial CSF control vehicle or the Ca++ ion channel blocking agent, verapamil, was perfused for 30 min by means of push-pull cannulae at a rate of 25.0 microliters/min. Verapamil 0.4, 2.0 and 4.0 micrograms/microliter) induced a concentration-dependent hypothermia when perfused within AH/POA sites but hyperthermia when perfused in the caudal hypothalamus. An anatomical analysis of the sites of perfusion revealed that verapamil's thermolytic effect was localized within the classical thermosensitive region of the cat's diencephalon, a region ventral to the anterior commissure and dorsal to the optic chiasm. On the other hand, the loci in which verapamil evoked thermogenesis were localized to a region dorsal to the mammillary bodies and caudal to the descending columns of the fornix. It is suggested that verapamil interferes with Ca++ ion channels ...Continue Reading

References

Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·N P Pillai, D H Ross
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·T F LeeR D Myers
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Atlas, M Adler
Dec 1, 1980·The American Journal of Cardiology·P D Henry
Jan 10, 1984·The Journal of Comparative Neurology·J Szabo, W M Cowan
Oct 11, 1982·Life Sciences·P J MarangosA M Martino

Citations

Jan 1, 1992·Psychopharmacology·O Pucilowski
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·R de Beaurepaire, W J Freed
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·M PalmiG Sgaragli
Apr 1, 1991·Brain Research Bulletin·O PucilowskiD S Janowsky
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Liza LeventhalDarlene Deecher
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Srinivas GullapalliPoduri Ramarao
Sep 6, 2002·Neuropharmacology·S AhleniusM Schultzberg
Jun 1, 1991·The Journal of Pharmacy and Pharmacology·O PucilowskiD S Janowsky

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