PMID: 7544142Aug 1, 1995Paper

Neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice

Neuron
P PiccioliAntonino Cattaneo

Abstract

Recombinant antibodies are efficiently secreted by cells of the nervous system. Thus, their local expression in the CNS of transgenic mice could be used to perturb the function of the corresponding antigen. As a first application of this approach, we have generated transgenic mice that express antibodies against the neuropeptide substance P, under the transcriptional control of the promoter of the neuronal gene vgf. The transgenic antibodies are expressed in a tissue-specific and developmentally regulated manner and are effective in competing with the endogenous substance P, as demonstrated by a marked inhibition of neurogenic inflammation and by motor deficits. This phenotypic knockout approach may provide a complementary alternative to gene knockout by homologous recombination.

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Citations

Sep 1, 2006·Cellular and Molecular Neurobiology·Simona Capsoni, Antonino Cattaneo
Mar 1, 2003·Frontiers in Neuroendocrinology·Sara Wells, David Murphy
Oct 10, 1998·Pain·Jeffrey S Mogil, Judith E Grisel
Sep 1, 1996·Trends in Endocrinology and Metabolism : TEM·G L Ferri, R Possenti
Oct 24, 1998·The European Journal of Neuroscience·M Kouznetsova, A Nistri
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Simona CapsoniAntonino Cattaneo
Mar 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Antonino Cattaneo
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·S CapsoniA Cattaneo
May 20, 2000·Neuropharmacology·T HökfeltM Diez
Jul 17, 2009·Neurobiology of Aging·Mara D'OnofrioAntonino Cattaneo
Apr 21, 2007·Journal of Molecular Recognition : JMR·Thomas Werge
Feb 24, 2015·Frontiers in Endocrinology·Jo E LewisPreeti H Jethwa
Feb 19, 2000·Journal of Neuroscience Research·S CapsoniA Cattaneo

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