Abstract
Diffuse vascular encephalopathy, parkinsonism and peripheral polyneuropathy (PNP) due to CS(2) exposure are known since long. Data concerning low exposure are sparse. The current study aimed to evaluate whether the decrease of exposure below the threshold limit value (TLV) of 31 mg/m(3) results in an absence of neurological health effects using the same health outcomes as in the first study. The study was conducted in a group of workers of a viscose rayon plant and a control group (CG, n=66). The exposed group was divided into two groups, according to the average CS(2) exposure being below (EG1; n=60) or above 31 mg/m(3) (EG2; n=25). If the current TLV seemed insufficient to prevent effects, the analysis was repeated with three subgroups (10, >10 to 30, >30 mg/m(3)) to estimate the NOEL. Every participant filled in the neurotoxicity symptom checklist (NSC-60) and the Q16. Clinical neurological examination, computer-assisted neurobehavioral tests (NES) and neurophysiological examinations (nerve conduction velocities and electromyography (EMG)) were performed. Sensorimotor complaints (NSC-60) were significantly worse in both EG1 and EG2 compared to CG (p=0.032) and both exposure groups had a higher proportion of positional tremor...Continue Reading
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