PMID: 9638682Jun 25, 1998Paper

Neurobehavioral and pregnancy effects of prenatal zidovudine exposure in Sprague-Dawley rats: preliminary findings

Neurotoxicology and Teratology
L E Applewhite-BlackH Minkoff

Abstract

In 1994, the Public Health Service made prenatal zidovudine (ZDV, AZT) the standard of care to prevent mother-to-child transmission of HIV. The current study was undertaken to determine if prenatal exposure to ZDV has an impact on pregnancy outcomes, birth anomalies, or offspring behavior in an animal model using Sprague-Dawley (SD) rats. Thirty-one virgin female SD rats were mated and randomly assigned to receive either ZDV at 150 mg/kg/day or vehicle via gastric intubation for 22 days starting on gestation day (G) 1. On G 22, teratologic examination of 12 litters showed no gross structural malformations. There were no significant differences between the groups for maternal food and water consumption or maternal weight gain across pregnancy. However, ZDV treatment significantly reduced litter size and increased birth weights for both male and female pups. One developmental milestone, pinna detachment, occurred significantly earlier in the ZDV-exposed male pups compared to the vehicle-intubated male controls. On day 21-22 of life, pups in each litter were injected with one of four doses of amphetamine and were observed for behavioral activity in a photobeam-based activity monitor for 1 h. Overall amphetamine increased activity ...Continue Reading

References

Mar 26, 1992·The New England Journal of Medicine·R S SperlingH Minkoff
Apr 7, 1992·European Journal of Pharmacology·C Van HartesveldtM E Meyer
Jun 1, 1991·The Journal of Infectious Diseases·P ToltzisE V Schmidt
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·M A GeyerV L Masten
May 1, 1987·Pharmacology, Biochemistry, and Behavior·G D Carr, N M White
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J L Stuckhardt, S M Poppe
Sep 1, 1994·Scandinavian Journal of Psychology·S BéatriceR K Selander
Jun 10, 1994·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Aug 1, 1993·Antimicrobial Agents and Chemotherapy·P ToltzisT Magnuson

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Citations

Mar 6, 2004·Neurotoxicology and Teratology·Edward D LevinG Jean Harry
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·G CalamandreiE Alleva
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·Y Busidan, D L Dow-Edwards
Aug 22, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aldina VenerosiEnrico Alleva
Dec 4, 2002·Neurotoxicology and Teratology·Susan M MelnickDiana L Dow-Edwards
Aug 10, 1999·Neurotoxicology and Teratology·Y Busidan, D L Dow-Edwards
Aug 10, 1999·Neurotoxicology and Teratology·G CalamandreiE Alleva
Jul 5, 2005·Neurotoxicology and Teratology·Susan M MelnickDiana L Dow-Edwards
Apr 4, 2002·Drugs·Gideon KorenArne Ohlsson

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