Neurobehavioral aspects of developmental toxicity testing

Environmental Health Perspectives
B Ulbrich, A K Palmer

Abstract

Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of animal species and data evaluation. Other problematic areas of study design and conduct, selection of litter representatives for testing, what methods to combine in a testing battery, and statistical treatment of results and their interpretation, will need more research and discussion in the future.

References

Sep 1, 1990·Neurotoxicology and Teratology·L P Spear
Nov 1, 1987·Neurotoxicology and Teratology·H A Tilson
Nov 1, 1987·Neurotoxicology and Teratology·C V Vorhees
Sep 1, 1981·Archives of Toxicology·G Zbinden

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Citations

Apr 27, 2001·Toxicology Letters·C A Kimmel, S L Makris
Nov 17, 2011·Critical Reviews in Toxicology·Robyn L PrueittLorenz R Rhomberg
Jul 22, 2005·Neurotoxicology and Teratology·Virginia C Moser
Mar 31, 2000·Toxicology and Applied Pharmacology·L ClaudioD Wallinga
Feb 11, 2000·Toxicologic Pathology·H A Tilson
Aug 14, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lawrence D MiddaughMurray R Selwyn
Jun 15, 2010·Inhalation Toxicology·Gary GinsbergMichael Firestone
Jun 15, 2000·Environmental Health Perspectives·B Weiss

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