Neurobehavioral correlates of obesity are largely heritable

Proceedings of the National Academy of Sciences of the United States of America
Uku VainikAlain Dagher

Abstract

Recent molecular genetic studies have shown that the majority of genes associated with obesity are expressed in the central nervous system. Obesity has also been associated with neurobehavioral factors such as brain morphology, cognitive performance, and personality. Here, we tested whether these neurobehavioral factors were associated with the heritable variance in obesity measured by body mass index (BMI) in the Human Connectome Project (n = 895 siblings). Phenotypically, cortical thickness findings supported the "right brain hypothesis" for obesity. Namely, increased BMI is associated with decreased cortical thickness in right frontal lobe and increased thickness in the left frontal lobe, notably in lateral prefrontal cortex. In addition, lower thickness and volume in entorhinal-parahippocampal structures and increased thickness in parietal-occipital structures in participants with higher BMI supported the role of visuospatial function in obesity. Brain morphometry results were supported by cognitive tests, which outlined a negative association between BMI and visuospatial function, verbal episodic memory, impulsivity, and cognitive flexibility. Personality-BMI correlations were inconsistent. We then aggregated the effects f...Continue Reading

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Citations

Jan 23, 2019·The European Journal of Neuroscience·Uku VainikAlain Dagher
Apr 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Uku VainikRené Mõttus
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Sep 24, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Isabel Garcia-GarciaAlain Dagher

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