Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union

The Journal of Clinical Endocrinology and Metabolism
Martine BellangerLeonardo Trasande

Abstract

Epidemiological studies and animal models demonstrate that endocrine-disrupting chemicals (EDCs) contribute to cognitive deficits and neurodevelopmental disabilities. The objective was to estimate neurodevelopmental disability and associated costs that can be reasonably attributed to EDC exposure in the European Union. An expert panel applied a weight-of-evidence characterization adapted from the Intergovernmental Panel on Climate Change. Exposure-response relationships and reference levels were evaluated for relevant EDCs, and biomarker data were organized from peer-reviewed studies to represent European exposure and approximate burden of disease. Cost estimation as of 2010 utilized lifetime economic productivity estimates, lifetime cost estimates for autism spectrum disorder, and annual costs for attention-deficit hyperactivity disorder. Setting, Patients and Participants, and Intervention: Cost estimation was carried out from a societal perspective, ie, including direct costs (eg, treatment costs) and indirect costs such as productivity loss. The panel identified a 70-100% probability that polybrominated diphenyl ether and organophosphate exposures contribute to IQ loss in the European population. Polybrominated diphenyl eth...Continue Reading

Citations

Dec 25, 2015·Chemical Research in Toxicology·Diana Montes-GrajalesJesus Tadeo Olivero-Verbel
Jan 10, 2016·The Science of the Total Environment·Golnoush AbbasiMiriam L Diamond
Jan 9, 2016·Critical Reviews in Food Science and Nutrition·Ilaria PaterniFilippo Minutolo
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Gian Carlo Di RenzoLinda C Giudice
Jul 28, 2016·The Lancet. Diabetes & Endocrinology·Tim I M Korevaar, Robin P Peeters
Jul 16, 2016·Journal of Epidemiology and Community Health·Leonardo TrasandeRobert Thomas Zoeller
Mar 9, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Louise RamhøjMarta Axelstad
Oct 28, 2017·Environmental Health : a Global Access Science Source·Axel MiePhilippe Grandjean
Dec 6, 2017·Environmental Health : a Global Access Science Source·Philippe Grandjean, Martine Bellanger
Nov 1, 2017·Journal of Dietary Supplements·Iyekhoetin Matthew Omoruyi, Raimo Pohjanvirta
Aug 2, 2016·Environmental Health Perspectives·Deborah BennettUNKNOWN National Medical Association
Jul 15, 2018·Journal of Molecular Endocrinology·Karen J OliveiraTania Maria Ortiga-Carvalho
Sep 25, 2017·Nature Reviews. Endocrinology·Bilal B Mughal, Barbara A Demeneix
Oct 17, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Océane AlbertBernard Robaire
Jul 6, 2019·Biologie aujourd'hui·Jean-Baptiste Fini, Barbara Demeneix
Jun 13, 2018·Environmental Engineering Science·Donald LucasCatherine P Koshland
Aug 17, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Morgan E Hernandez ScudderAndrea C Gore
Feb 26, 2016·Thyroid : Official Journal of the American Thyroid Association·Angela M LeungBarbara A Demeneix
Jul 28, 2017·Environmental Health : a Global Access Science Source·Youn-Hee LimYun-Chul Hong
Nov 18, 2018·Environmental Health : a Global Access Science Source·Axel MiePhilippe Grandjean
Jan 11, 2020·Frontiers in Endocrinology·Michelle LeemansJean-Baptiste Fini
Apr 26, 2020·International Journal of Molecular Sciences·Henrik HolbechLisa Baumann
Apr 1, 2016·Current Environmental Health Reports·Maricel V MaffiniThomas G Neltner
Apr 25, 2018·Environmental Health : a Global Access Science Source·Jean-Pierre BourguignonNicolas Van Larebeke
Apr 5, 2019·Environmental Health : a Global Access Science Source·Axel MiePhilippe Grandjean
Jun 11, 2017·Environmental Health : a Global Access Science Source·Radka PrichystalovaLaura Maxim
May 24, 2020·The Lancet. Diabetes & Endocrinology·Barbara A Demeneix
Jan 4, 2021·Journal of Hazardous Materials·Marta SendraBeatriz Novoa
Feb 20, 2021·The Lancet Global Health·Hanna-Andrea Rother
Mar 11, 2021·Environmental Health Perspectives·Devon C Payne-SturgesPeter S Hovmand
Jul 25, 2020·The Lancet. Diabetes & Endocrinology·Christopher D KassotisLeonardo Trasande

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.