Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals

Biological Trace Element Research
Tian TianBao-liang Sun

Abstract

The ketogenic diet (KD) has been shown to be effective as an antiepileptic therapy in adults, but it has not been extensively tested for its efficacy in neonatal seizure-induced brain damage. We have previously shown altered expression of zinc/lipid metabolism-related genes in hippocampus following penicillin-induced developmental model of epilepsy. In this study, we further investigated the effect of KD on the neurobehavioral and cognitive deficits, as well as if KD has any influence in the activity of zinc/lipid transporters such as zinc transporter 3 (ZnT-3), MT-3, ApoE, ApoJ (clusterin), and ACAT-1 activities in neonatal rats submitted to flurothyl-induced recurrent seizures. Postnatal day 9 (P9), 48 Sprague-Dawley rats were randomly assigned to two groups: flurothyl-induced recurrent seizure group (EXP) and control group (CONT). On P28, they were further randomly divided into the seizure group without ketogenic diet (EXP1), seizure plus ketogenic diet (EXP2), the control group without ketogenic diet (CONT1), and the control plus ketogenic diet (CONT2). Neurological behavioral parameters of brain damage (plane righting reflex, cliff avoidance reflex, and open field test) were observed from P35 to P49. Morris water maze test...Continue Reading

References

Jan 1, 1995·The International Journal of Biochemistry & Cell Biology·A A Shaheen, A A el-Fattah
Feb 13, 1999·The European Journal of Neuroscience·E Y KimB J Gwag
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·T B ColeR D Palmiter
Mar 7, 2002·The Journal of Nutrition·Denize R ZieglerCarlos-Alberto Gonçalves
Dec 19, 2003·The Journal of Biological Chemistry·Joo-Yong LeeJae-Young Koh
Aug 30, 2005·Metabolism: Clinical and Experimental·Ameer Y TahaStephen C Cunnane
Aug 23, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·David H LinkousChristopher J Frederickson
Jun 19, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sang Won SuhJialing Liu
Jun 18, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Joo-Yong LeeJae-Young Koh
May 28, 2011·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S S ChristodoulidesJ H Cross
Aug 26, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kamille Smidt, Jørgen Rungby
May 15, 2013·Journal of Child Neurology·Nika N DanialLiu Lin Thio
Sep 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dayane Pessoa de AraújoSilvânia Maria Mendes Vasconcelos
Nov 10, 2013·Neurobiology of Aging·Timothy M HughesLewis H Kuller
Nov 28, 2013·Brain : a Journal of Neurology·Stefanie GrabruckerAndreas M Grabrucker
Sep 10, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bo Young ChoiSang Won Suh
Oct 15, 2014·Journal of Neurochemistry·Yifan ZhangMichelle A Puchowicz

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Citations

Sep 11, 2019·The European Journal of Neuroscience·Amen WiqasRae Silver
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
Jul 13, 2019·Epilepsy & Behavior : E&B·Yifan LiangChuansheng Zhao

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