Neurobehavioral effects of dental amalgam in children: a randomized clinical trial.

JAMA : the Journal of the American Medical Association
Timothy A DeRouenIsabel P Martins

Abstract

Dental (silver) amalgam is a widely used restorative material containing 50% elemental mercury that emits small amounts of mercury vapor. No randomized clinical trials have determined whether there are significant health risks associated with this low-level mercury exposure. To assess the safety of dental amalgam restorations in children. A randomized clinical trial in which children requiring dental restorative treatment were randomized to either amalgam for posterior restorations or resin composite instead of amalgam. Enrollment commenced February 1997, with annual follow-up for 7 years concluding in July 2005. A total of 507 children in Lisbon, Portugal, aged 8 to 10 years with at least 1 carious lesion on a permanent tooth, no previous exposure to amalgam, urinary mercury level <10 microg/L, blood lead level <15 microg/dL, Comprehensive Test of Nonverbal Intelligence IQ > or =67, and with no interfering health conditions. Routine, standard-of-care dental treatment, with one group receiving amalgam restorations for posterior lesions (n = 253) and the other group receiving resin composite restorations instead of amalgam (n = 254). Neurobehavioral assessments of memory, attention/concentration, and motor/visuomotor domains, as...Continue Reading

Associated Clinical Trials

Citations

Jan 25, 2014·British Dental Journal·F L TrachtenbergN N Maserejian
Jul 11, 2009·Environmental Health Perspectives·Robin LeeMichelle Watters
Jan 15, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kristin G HommeMark R Geier
Jul 6, 2013·Neurotoxicology and Teratology·James S WoodsFederico M Farin
Nov 19, 2014·Environmental Health : a Global Access Science Source·Jennifer D ZwickerJohn Charles Herbert Emery
Jun 28, 2008·Evidence-based Dentistry·P BogowiczG Heo
Nov 6, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·David A GeierMark R Geier
Feb 22, 2008·Environmental Health Perspectives·Nancy Nairi MaserejianLars Barregard
Mar 12, 2008·Current Opinion in Pediatrics·Emily Oken, David C Bellinger
Mar 13, 2008·Environmental Health Perspectives·Lars BarregardSonja McKinlay
Apr 25, 2008·Journal of Dental Research·D C BellingerS McKinlay
Jun 28, 2008·The Journal of Antimicrobial Chemotherapy·Olusegun O SogeMarilyn C Roberts
Aug 23, 2008·Journal of Dental Research·Q YeP Spencer
Mar 3, 2010·Annals of Biomedical Engineering·Paulette SpencerJ Lawrence Katz
Nov 18, 2010·Environmental Health Perspectives·Aimin ChenShuk-mei Ho
Sep 11, 2013·BMC Oral Health·Alexandra NicolaeCarlos Quiñonez
Jun 15, 2012·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Isabel Pavão MartinsBrenda D Townes
Dec 7, 2011·International Journal of Dentistry·Yurdanur Uçar, William A Brantley
Sep 14, 2007·Journal of Exposure Science & Environmental Epidemiology·Lubica PalkovicovaIrva Hertz-Picciotto
May 14, 2009·Journal of Environmental Monitoring : JEM·Bernhard MichalkeVolker Nischwitz
Jun 24, 2008·The International Journal of Neuroscience·Brenda D TownesMario Bernardo
Oct 19, 2006·Expert Opinion on Drug Safety·Michael D Martin, James S Woods
Feb 3, 2016·International Dental Journal·Hye-Jin BaekYoun-Hee Choi
Nov 29, 2011·The Urologic Clinics of North America·Mark A Moyad
May 24, 2011·The Science of the Total Environment·Iman Al-Saleh, Al Anoud Al-Sedairi
Jun 29, 2010·La Revue de médecine interne·L Bensefa-ColasA Descatha
Feb 14, 2009·Dental Clinics of North America·Jane GilletteRobert J Weyant
May 22, 2008·The Journal of Evidence-based Dental Practice·Elliot Abt
Oct 17, 2007·The Psychiatric Clinics of North America·James S Brown
Dec 7, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Michael D MartinJohn Kushleika
Apr 15, 2016·Dental Research Journal·Laura Yueh-Guey Huang, Boyen Huang
Jun 26, 2007·Dental Clinics of North America·Kenneth R St John
Mar 17, 2007·The Science of the Total Environment·Michael D MartinTimothy A DeRouen
Apr 24, 2007·Pediatric Clinics of North America·Jack C Clifton
Sep 5, 2008·International Journal of Dental Hygiene·H S LuísJ Leitão
Aug 30, 2008·Developmental Medicine and Child Neurology·Isabel MartinsBrenda Townes
Mar 21, 2008·International Dental Journal·M J McCullough, M J Tyas

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