Neurobehavioral effects of uremic toxin-indoxyl sulfate in the rat model.

Scientific Reports
Malgorzata KarbowskaDariusz Pawlak

Abstract

Chronic kidney disease (CKD) is deemed to be a worldwide health concern connected with neurological manifestations. The etiology of central nervous system (CNS) disorders in CKD is still not fully understood, however particular attention is currently being paid to the impact of accumulated toxins. Indoxyl sulfate (IS) is one of the most potent uremic toxins. The purpose of the present study was to assess IS concentrations in the cerebellum, brainstem, cortex, hypothalamus, and striatum with hippocampus of rats chronically exposed to IS. To evaluate IS impact on neurochemical and behavioral alterations, we examined its influence on brain levels of norepinephrine, epinephrine, dopamine, serotonin and their metabolites, as well as changes in behavioral tests (open field test, elevated plus maze test, chimney test, T maze test, and splash test). Our results show the highest IS accumulation in the brainstem. IS leads to behavioral alterations involving apathetic behavior, increased stress sensitivity, and reduced locomotor and exploratory activity. Besides, IS contributes to the impairment of spatial memory and motor coordination. Furthermore, we observed reduced levels of norepinephrine, dopamine or serotonin, mainly in the brainst...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
May 1, 1977·The American Journal of Physiology·F SiassiM E Swendseid
Jan 26, 2000·Metabolic Brain Disease·M Al BanchaabouchiP P De Deyn
Mar 29, 2001·The Journal of Pharmacy and Pharmacology·S Anoopkumar-DukieS Daya
Jun 9, 2009·Rapid Communications in Mass Spectrometry : RCM·Ganfeng Wang, Walter A Korfmacher
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Toshimitsu Niwa
Jun 22, 2012·Journal of Chromatographic Science·Mohammed Al Za'abiMohammed Al Toubi
Oct 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Ippei WatanabeToshisuke Morita
Dec 25, 2013·Handbook of Clinical Neurology·Martin W BaumgaertelPeter Berlit
Mar 8, 2014·Clinics in Orthopedic Surgery·Jeehyoung Kim, Wonshik Shin
Jul 9, 2014·Neurotoxicology·Kimio WatanabeMasaaki Nakayama
Jul 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Arkom NongnuchAndrew Davenport
Apr 1, 2015·European Journal of Pharmacology·Melanie L Graham, Mark J Prescott
Aug 7, 2017·Seminars in Pediatric Neurology·Jorge H Baluarte

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Citations

Jul 3, 2021·International Journal of Molecular Sciences·Chia-Ter Chao, Shih-Hua Lin
Jan 7, 2022·Metabolomics : Official Journal of the Metabolomic Society·George E JaskiwCurtis J Donskey

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