PMID: 9174242May 20, 1997Paper

Neurobehavioral evaluation of lurcher mutant mice during ontogeny

Brain Research. Developmental Brain Research
F ThullierF Lestienne

Abstract

Lurcher mutant mice were compared to normal littermate controls for body weight, body righting, negative geotropism, sensorimotor coordination (rotating grid, wire suspension, rotorod), and visuomotor coordination requiring swimming toward a pole during postnatal (P) days 0-30. Lurcher mutants had a lower body weight on P20-P30 and were slower before performing the complete body righting response on P13-P30. Because of postural instability during the negative geotropism test, lurcher mutants turned quicker up the slope than normal mice. The mutants fell sooner from the rotating grid on P11-P14, from the horizontal wire on P15-P16, and from the rotorod on P14-P30. Lurcher mutants were also slower before swimming to the pole or climbing to the top of the pole and were inferior in pole climbing height on P22-P30. These results indicate test-selective and time-selective neurobehavioral deficits during ontogeny in a spontaneous cerebellar mutant.

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Citations

Jul 2, 1999·Journal of Neuroscience Methods·P HilberJ Caston
Mar 23, 2004·Behavioural Brain Research·Alena Krízková, Frantisek Vozeh
Feb 28, 2001·Neuroscience·P Hilber, J Caston
May 31, 2012·Molecular and Cellular Biology·Kazuhiro NakamuraKun Ping Lu
Jan 18, 2006·Brain Research·Michael W VogelJean Mariani
Apr 25, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Robert Lalonde, Catherine Strazielle
Feb 4, 2010·Behavioural Brain Research·Jan CendelínFrantisek Vozeh
Dec 25, 2004·Behavioural Brain Research·R LalondeC Strazielle
Jan 1, 2014·Cerebellum & Ataxias·Jan Cendelin
Jun 11, 2009·Nature Reviews. Neuroscience·Simon P Brooks, Stephen B Dunnett
Dec 18, 2015·Physiological Research·F VoŽeh
Aug 22, 2000·Journal of Neuropathology and Experimental Neurology·C StrazielleT A Reader
Dec 25, 2009·Neuroscience and Behavioral Physiology·N M Dubrovskaya, I A Zhuravin
Nov 20, 2016·The Cerebellum·František Vožeh

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