Neurobehavioral outcome in pediatric craniopharyngioma

Pediatric Neurosurgery
C A AndersonB K Kleinschmidt-DeMasters

Abstract

Neurobehavioral dysfunction occurs in children with craniopharyngioma, both before and after treatment, and its impact on outcome may not be fully appreciated. Also unclear is whether neurobehavioral outcome relates more to tumor location or surgical factors. We reviewed the records of 20 children with craniopharyngioma who were seen between 1983 and 1995. All children had subfrontal craniotomy and either partial (14 children) or gross total (6 children) resection of their tumors. In addition to traditional neuropsychological testing, we assessed social behavior and school performance using standardized ratings based on family interviews and school records. Over a mean follow-up period of 38 months, only 3 of 20 children had a good outcome in all three categories, and 12 of 20 had moderate or severe impairment in at least one category. Outcome did not differ between those who had partial and those with gross total resection. We conclude that neurobehavioral disorders are common and cause important morbidity in children after treatment for craniopharyngioma. To evaluate these impairments in future outcome studies, standard neuropsychological testing should be supplemented by specific behavioral assessments to capture the full ra...Continue Reading

Citations

May 13, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hermann L MüllerNiels Sörensen
Mar 17, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthieu VinchonIsabelle Delestret
Jun 11, 2010·Journal of Neuro-oncology·Michael E SughrueAndrew T Parsa
Jun 9, 2012·Pituitary·Hermann L Müller
Sep 11, 2012·Pituitary·Eva Marie ErfurthSigridur Bara Fjalldal
Dec 21, 2000·Current Treatment Options in Neurology·D D Eisenstat
Jul 9, 2008·Journal of Clinical and Experimental Neuropsychology·Harry N BawdenRachel Morehouse
Apr 7, 2010·Neurosurgical Focus·Isaac YangAndrew T Parsa
Jul 24, 2002·Journal of Neurosurgery·Rémy Van Effenterre, Anne-Laure Boch
Dec 10, 2013·Journal of Neurosurgery. Pediatrics·Zarina S AliSherman C Stein
Aug 29, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tilman SchubertGuido Nikkhah
Aug 13, 2013·Critical Reviews in Oncology/hematology·Pietro MortiniMarco Losa
Mar 29, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Robert I SmeeWarwick Stening
Feb 5, 2009·Pediatric Blood & Cancer·Eugenia P DolsonThomas E Merchant
Jan 15, 2011·Developmental Medicine and Child Neurology·Jennifer L Hammond, Scott S Hall
Nov 9, 2006·Advances in Pediatrics·Joshua A MayMitchell E Geffner
Feb 11, 2014·The Journal of Pediatrics·Jale ÖzyurtHermann L Müller
Mar 18, 2006·Endocrine Reviews·Niki KaravitakiJohn A H Wass
Jan 29, 2014·Endocrine Reviews·Hermann L Müller
Dec 17, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Eva Marie Erfurth
Feb 26, 2000·Neurosurgery·J DuffB W Scheithauer
Jan 30, 2003·Medical and Pediatric Oncology·John A KalapurakalMaryanne H Marymont
Aug 24, 2012·Journal of Neuro-oncology·Todd C HankinsonArthur K Liu
Sep 16, 2015·Journal of Neuro-oncology·Jale ÖzyurtChristiane M Thiel
Jul 7, 2021·Journal of the Academy of Consultation-Liaison Psychiatry·Alvin KengKathleen Ann Sheehan

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