Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease

International Archives of Occupational and Environmental Health
Dag G EllingsenValery Chashchin

Abstract

There is a lack of knowledge about neurobehavioral performance among patients with manganism and how their performance differs from that of idiopathic Parkinson disease patients (PD). This study was initiated with the aim to describe and compare neurobehavioral performance among patients diagnosed with manganism, PD and a group of referents. Neurobehavioral performance was assessed in 34 patients diagnosed with manganism, 13 with PD, and 43 healthy workers (turners/fitters) who served as the reference group. Seventeen of the manganism patients had also been tested approximately 65 months previously. Manganism patients scored substantially more poorly than referents on tests for motor speed, manual dexterity and balance. They also performed more poorly than the PD patients on the postural sway test. In contrast, the PD patients had higher postural tremor intensity with narrower frequency dispersion than manganism patients. The pattern of neurobehavioral performance was more asymmetrical in PD compared to manganism patients, in particular when testing for tremor intestity, grooved pegboard and static steadiness, indicating lateralized impairment in the PD patients. The amount of bradykinesia was comparable between the patient gro...Continue Reading

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Citations

Nov 23, 2019·Molecular Neurobiology·Geir BjørklundJan Aaseth
Apr 17, 2020·Journal of Agricultural and Food Chemistry·Airton C MartinsMichael Aschner

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