Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data

Reproductive Toxicology
Asher Ornoy

Abstract

During the last twenty years, in spite of extensive literature regarding the use of SSRIs in pregnancy, confusion still exists as to possible long-term risks of these drugs on the offspring. Possible negative effects relate to neurodevelopmental outcome and association with Autism Spectrum Disorder (ASD). Most neurodevelopmental follow up studies did not find significant cognitive impairment except from some apparently transient, gross motor delay and slight impairment of language abilities. The literature on the possible association of SSRIs with ASD is inconsistent, and if an association exists it is apparently throughout pregnancy. There is a higher risk for psychiatric problems which might be related to the maternal psychiatric disease for which SSRIs were prescribed. Most animal studies did not demonstrate teratogenicity, and the observed neurodevelopmental problems are of models with depression induced during pregnancy. Depression seems to be associated with up regulation of hypothalamic pituitary adrenal (HPA) axis and prenatal SSRIs also seem to affect the HPA axis in animals and man, but the possible long-term outcome has yet to be established. SSRIs might apparently also induce epigenetic changes. There is, however, l...Continue Reading

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Citations

Oct 5, 2018·Molecular Psychiatry·Kristi M SawyerCarmine M Pariante
Jan 19, 2018·Expert Opinion on Drug Metabolism & Toxicology·Asher Ornoy, Gideon Koren
Aug 23, 2020·International Journal of Molecular Sciences·Sabrina I HanswijkJudith R Homberg

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