PMID: 8947948Nov 1, 1996Paper

Neurobehavioral study of prenatal exposure to hyperthermia combined with irradiation in mice

Neurotoxicology and Teratology
D Z ZhongL Xiu-Qin

Abstract

Thirty-two pregnant adult LACA mice were randomly assigned to one of five exposure groups: control, 38 degrees C, 42 degrees C, irradiation, and 42 degrees C + irradiation. Animals were exposed on gestation day 9 to either 38 degrees C waterbath for 5 min, 42 degrees C waterbath for 5 min, treatment with 0.5 Gy of 60Co gamma irradiation, or pretreatment at 42 degrees C waterbath for 5 min following by 0.5 Gy of 60CO gamma irradiation. On postnatal day 7, litters were reduced to a maximum of eight pups per litter, with equal members of male and female offspring whenever possible. A total of 216 pups were observed for the age of acquisition of four physiological landmarks (pinna detachment, incisor eruption, eye opening, testes descent), six developmental reflexes (surface righting, cliff avoidance, auditory startle, air righting, visual placing, hindlimb splaying), and examination of learning and memory function. These studies, at threshold exposure levels to hyperthermia and ionizing radiation, indicate there is no consistent significant additional postnatal effect when pregnant mice are exposed to both of these agents. These studies are important for our understanding of the relative long-range effects of prenatal exposure to ...Continue Reading

References

Jan 1, 1988·Teratology·G F Chernoff, J A Golden
Oct 1, 1987·Teratology·D A WalshM J Edwards
Feb 1, 1986·Teratology·F W Rosa
Apr 1, 1986·Teratology·R H FinnellG F Chernoff
Jun 1, 1984·Teratology·W S Webster, M J Edwards
Mar 1, 1993·Teratology·C A KimmelJ Chen
Mar 1, 1993·Teratology·G L KimmelP M Silverman

❮ Previous
Next ❯

Citations

Jan 23, 1999·Teratology·C D ChambersK L Jones
Sep 7, 2000·Neurotoxicology and Teratology·R Baskar, P U Devi
May 29, 2012·Environmental Pollution·Nathalie VanhoudtKarolina Stark
Apr 19, 2017·Radiation Research·Shayenthiran SreetharanT C Tai
Oct 9, 2003·Annals of the ICRP·Roger Cox, Christian Streffer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.