Neurobehavioural Changes in a Hemiparkinsonian Rat Model Induced by Rotenone

Journal of Clinical and Diagnostic Research : JCDR
Sukala Puthuparambil ManiyathMuthusamy Rathinasamy

Abstract

Rotenone, a mitochondrial complex I inhibitor is used as a neurotoxin agent to reproduce the neuropathological, and behavioural feature of Parkinson's Disease (PD) in rat. Due to acute and chronic exposure of rotenone with various doses through different routes of administration, mortality is being reported. Low dose takes a longer duration to produce PD symptoms in animals. This present study was designed to create hemiparkinsonian 'partial' lesion model by rotenone at a single moderate dose in two sites of striatum in albino rats and also to assess its toxicity by behavioural parameters and by microscopic study. To assess all the motor deficits in lesioned animals that are due to the depletion of dopaminergic neurons or its terminals, the lesioned animals were administered with anti-parkinsonian drug, Levodopa which should counteract motor deficits in rats. The unilateral partially lesioned PD model was induced by rotenone stereotaxically into two sites of striatum of male Wistar albino rats at a dosage of 25 μg of rotenone/site. Rats were tested for its neurobehavioural activity on 7(th) day, 14(th) day, 21(st) day and on 30(th) day after rotenone infusion and compared with the sham group and sacrificed on 21(st) and 30(th) ...Continue Reading

Citations

Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lili TangYang Zhao

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