Neurobiological and clinical effects of fNIRS-controlled rTMS in patients with panic disorder/agoraphobia during cognitive-behavioural therapy

NeuroImage. Clinical
Saskia DeppermannP Zwanzger

Abstract

A relevant proportion of patients with panic disorder (PD) does not improve even though they receive state of the art treatment for anxiety disorders such as cognitive-behavioural therapy (CBT). At the same time, it is known, that from a neurobiological point of view, PD patients are often characterised by prefrontal hypoactivation. Intermittent Theta Burst Stimulation (iTBS) is a non-invasive type of neurostimulation which can modulate cortical activity and thus has the potential to normalise prefrontal hypoactivity found in PD. We therefore aimed at investigating the effects of iTBS as an innovative add-on to CBT in the treatment for PD. In this double-blind, bicentric study, 44 PD patients, randomised to sham or verum stimulation, received 15 sessions of iTBS over the left prefrontal cortex (PFC) in addition to 9 weeks of group CBT. Cortical activity during a cognitive as well as an emotional (Emotional Stroop) paradigm was assessed both at baseline and post-iTBS treatment using functional near-infrared spectroscopy (fNIRS) and compared to healthy controls. In this manuscript we only report the results of the emotional paradigm; for the results of the cognitive paradigm please refer to Deppermann et al. (2014). During the Em...Continue Reading

Citations

Jan 31, 2019·Psychiatry Investigation·Morena M ZuglianiRafael C Freire
Dec 17, 2019·The American Journal of Psychiatry·Yunbo YangTilo Kircher
Jul 30, 2020·Scientific Reports·David RosenbaumAnn-Christine Ehlis
Jan 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurUlf Ziemann
Feb 3, 2021·Social Cognitive and Affective Neuroscience·Matthew M P WestgarthDavid H K Shum
Mar 7, 2020·NeuroImage. Clinical·David RosenbaumAnn-Christine Ehlis
May 19, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Miguel Ângelo Monteiro Devezas

❮ Previous
Next ❯

Methods Mentioned

BETA
cognitive-behavioural therapy
pharmacotherapy
imaging technique
cognitive behavioural therapy

Software Mentioned

Matlab

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.