Neurobiological background of negative symptoms

European Archives of Psychiatry and Clinical Neuroscience
Silvana GalderisiArmida Mucci

Abstract

Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct. We tried to review the findings published to date investigating neurobiological abnormalities after reducing the heterogeneity of the negative symptoms construct. The literature in electronic databases as well as citations and major articles are reviewed with respect to the phenomenology, pathology, genetics and neurobiology of schizophrenia. We searched PubMed with the keywords "negative symptoms," "deficit schizophrenia," "persistent negative symptoms," "neurotransmissions," "neuroimaging" and "genetic." Additional articles were identified by manually checking the reference lists of the relevant publications. Publications in English were considered, and unpublished studies, conference abstracts and poster presentations were not included. Structural and functional imaging studies addressed the issue of neurobiological background of negative symptoms from several perspectives (considering them as a unitary construct, focusing on primary and/or persistent negative symptoms and, more recently, clustering them into factors), but produced dis...Continue Reading

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Citations

Feb 26, 2016·NeuroImage. Clinical·S GuimondM Lepage
Sep 1, 2015·European Archives of Psychiatry and Clinical Neuroscience·Andrea Schmitt, Peter Falkai
May 28, 2016·The Nursing Clinics of North America·Deborah Antai-Otong
Dec 16, 2017·Clinical EEG and Neuroscience·Maria PontilloStefano Vicari
Oct 21, 2017·Biological Research for Nursing·Sasha S BinfordHeather Leutwyler
Feb 26, 2016·European Archives of Psychiatry and Clinical Neuroscience·Marta de Castro-CatalaAraceli Rosa
Sep 25, 2017·Frontiers in Human Neuroscience·Wei LiuBing Jin Li
May 28, 2019·Frontiers in Psychiatry·Alexandre Andrade Loch
Sep 2, 2020·International Journal of Environmental Research and Public Health·Tji Tjian CheeRoger Ho
Jul 21, 2017·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Jun 3, 2017·Schizophrenia Bulletin·Brian KirkpatrickSilvana Galderisi
Mar 6, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martin LepageAshok K Malla
Jul 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Venkataram ShivakumarGanesan Venkatasubramanian

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