Neurobiological markers of familial risk for depression

Current Topics in Behavioral Neurosciences
Lara C Foland-RossIan H Gotlib

Abstract

Major depression is associated with a wide range of neurobiological disturbances, including anomalies in the structure and function of cortical and subcortical gray matter and dysregulation of the HPA axis. In this chapter, we review research demonstrating that many of these abnormalities are also present in never-depressed offspring of adults with recurrent depression and discuss how such findings might reflect dysfunctional neuroregulatory systems that precede the onset of this disorder. We also briefly discuss candidate genes and environmental factors that have been posited to be directly involved in the transmission of neural and HPA-axis abnormalities from depressed parents to their offspring, and we review how, by obtaining a better understanding of the neurobiological markers of depression risk, we can facilitate the development of targeted strategies for the prevention and treatment of major depression.

Citations

May 3, 2013·Clinical Psychological Science : a Journal of the Association for Psychological Science·Michael L M MurphyGregory E Miller
Feb 19, 2016·Journal of the International Neuropsychological Society : JINS·Maki S KoyamaMichael P Milham
Jul 6, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ningning ZhangYuefeng Li
Jan 31, 2021·Journal of Affective Disorders·Giorgia MicheliniRoman Kotov
Aug 19, 2014·Biological Psychiatry·Curt A SandmanElysia Poggi Davis

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