Neurobiological processes during the Cambridge gambling task

Behavioural Brain Research
Kurosch YazdiRaimund Kleiser

Abstract

Although vast research has been conducted concerning gambling behavior this is the first study combining behavioral and functional magnetic resonance imaging (fMRI) data while using the Cambridge Gambling Task (CGT). We tested 20 healthy right-handed men and chose an event-related design to allow for precise temporal separation of gambling stages. In the color decision stage participants had to guess whether a yellow token was hidden behind red or blue boxes presented in varying color ratios, then stake wagers during the bet decision stage. In the final stage the outcome (won or lost) was presented. Analyzing the blood-oxygenation level-dependent (BOLD) contrasts in the decision stages we found increases of activation in brain areas involved in decision making, working memory and learning, when participants bet on the majority choice. During the outcome stage increased brain activation was found in parts of the reward system and areas involved in decision making and impulse control, when winning. When losing, activation increased in areas involved in risk aversion and management of uncertainties. When participants lost unexpectedly (i.e. lost although they bet on the majority), increased activation was found in the insula, comp...Continue Reading

References

Aug 28, 1998·Trends in Neurosciences·L W Swanson, G D Petrovich
Mar 2, 2002·Brain : a Journal of Neurology·Facundo ManesTrevor Robbins
Sep 5, 2002·Neuropsychologia·T L HodgsonC Kennard
Oct 18, 2002·Neuron·P Read Montague, Gregory S Berns
Jan 22, 2003·Nature Neuroscience·A K AndersonN Sobel
Apr 30, 2003·Neuron·John P O'DohertyRaymond J Dolan
Jan 27, 2004·Neuron·Elizabeth M TricomiJulie A Fiez
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahiko HarunoMitsuo Kawato
Apr 15, 2004·Current Opinion in Neurobiology·Peter C Holland, Michela Gallagher
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Samuel M McClureP Read Montague
Jul 6, 2004·Nature Neuroscience·Saori C TanakaShigeto Yamawaki
Aug 26, 2004·Neuropsychologia·Monique ErnstDaniel S Pine
Jan 18, 2005·NeuroImage·M R DelgadoE A Phelps
Jul 9, 2005·Current Opinion in Neurology·Brian Knutson, Jeffrey C Cooper
May 6, 2006·Neuron·R Alison AdcockJohn D E Gabrieli
Nov 24, 2006·Journal of Neurophysiology·Philippe N ToblerWolfram Schultz
Dec 8, 2007·Drug and Alcohol Dependence·F PassettiM King
Oct 3, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Brian Knutson, Stephanie M Greer
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paula L CroxsonMatthew F S Rushworth
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Oct 13, 2009·Psychological Medicine·D D PatelN A Fineberg
Mar 2, 2010·NeuroImage·Linda Van LeijenhorstEveline A Crone
Mar 30, 2011·Psychology and Aging·Luke ClarkKatalin Szanto
Jul 1, 2011·Psychiatry Research·Jon Edgar GrantSuck Won Kim
Jan 1, 2011·Translational Psychiatry·S KühnJ Gallinat
Jan 30, 2013·Journal of Psychiatric Research·Samuel R ChamberlainJon E Grant
Jul 19, 2013·Journal of Addiction Medicine·Arit M HarvankoJon E Grant
Oct 19, 2013·Frontiers in Psychology·Damien BreversXavier Noël

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