Neurobiology and consequences of social isolation stress in animal model-A comprehensive review

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Faiza MumtazAhmad Reza Dehpour

Abstract

The brain is a vital organ, susceptible to alterations under genetic influences and environmental experiences. Social isolation (SI) acts as a stressor which results in alterations in reactivity to stress, social behavior, function of neurochemical and neuroendocrine system, physiological, anatomical and behavioral changes in both animal and humans. During early stages of life, acute or chronic SIS has been proposed to show signs and symptoms of psychiatric and neurological disorders such as anxiety, depression, schizophrenia, epilepsy and memory loss. Exposure to social isolation stress induces a variety of endocrinological changes including the activation of hypothalamic-pituitary-adrenal (HPA) axis, culminating in the release of glucocorticoids (GCs), release of catecholamines, activation of the sympatho-adrenomedullary system, release of Oxytocin and vasopressin. In several regions of the central nervous system (CNS), SIS alters the level of neurotransmitter such as dopamine, serotonin, gamma aminobutyric acid (GABA), glutamate, nitrergic system and adrenaline as well as leads to alteration in receptor sensitivity of N-methyl-D-aspartate (NMDA) and opioid system. A change in the function of oxidative and nitrosative stress ...Continue Reading

References

Jan 1, 1977·Physiology & Behavior·B J Sahakian, T W Robbins
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·S M WhiteJ A Moyer
Jan 1, 1991·Psychopharmacology·I K WrightC A Marsden
Jun 1, 1991·Physiology & Behavior·P PopikJ M van Ree
Jan 1, 1987·Psychopharmacology·R DantzerM Le Moal
Aug 2, 1988·Brain Research·R DantzerM Le Moal
Jan 1, 1986·Physiology & Behavior·A GamalloA Fraile
Sep 1, 1965·Toxicology and Applied Pharmacology·A M HatchH C Grice
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·J PankseppF G DeEskinazi
Jan 1, 1984·Annual Review of Neuroscience·H AkilJ M Walker
Mar 1, 1980·Physiology & Behavior·A Morinan, B E Leonard
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jun 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L J VanderschurenJ M Van Ree
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·A Shekhar, J S Katner
Dec 29, 1995·Annals of the New York Academy of Sciences·R KvetnanskýI J Kopin
Jan 1, 1995·Journal of Neural Transmission. General Section·M PonceletG Le Fur
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·N Wongwitdecha, C A Marsden
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·R J Rodgers, A Dalvi
May 20, 1998·Pharmacology, Biochemistry, and Behavior·F S HallT W Robbins
Oct 21, 1998·Developmental Neuroscience·J B Clark
Dec 5, 1998·Neurochemistry International·K J Kovács
Jun 9, 1999·The American Journal of Psychiatry·K S KendlerC A Prescott
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Sep 25, 1999·Physiology & Behavior·V P Bakshi, M A Geyer

❮ Previous
Next ❯

Citations

Nov 13, 2019·Alcoholism, Clinical and Experimental Research·Ophelia EvansRaúl Pastor
Nov 30, 2019·The International Journal of Neuropsychopharmacology·Raffaella CalatiIgor Galynker
Oct 23, 2019·Annual Review of Physiology·Christi M GendronScott D Pletcher
Apr 10, 2020·ELife·Manon K Schweinfurth
May 28, 2020·The Journal of Experimental Biology·Alexis C ExumJens Herberholz
Jun 25, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·William BushellPaul J Mills
Jun 4, 2020·Molecular Psychiatry·Santosh PothulaRonald S Duman
Jun 24, 2020·Frontiers in Immunology·Ícaro RaonyWilson Savino
Apr 3, 2019·International Journal of Molecular Sciences·Andreina BajCristina Giaroni
Aug 15, 2020·Frontiers in Behavioral Neuroscience·Jean K Rivera-IrizarryKristen E Pleil
Nov 16, 2019·Social Neuroscience·Livia TomovaRebecca Saxe
Aug 6, 2019·American Journal of Surgery·Elizabeth S MillerAlicia M Mohr
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Jaume F Lalanza, Eelke M S Snoeren
Jan 27, 2021·International Journal of Molecular Sciences·Dorsa Rafiei, Nathan J Kolla
Nov 17, 2020·Frontiers in Systems Neuroscience·Jay Love, Moriel Zelikowsky
Oct 16, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Santosh PothulaRonald S Duman
Dec 31, 2020·International Journal of Molecular Sciences·Aleah HolmesVenugopal Reddy Venna
Nov 5, 2020·Brain Sciences·Nataliya A KrupinaNadezhda N Khlebnikova
Feb 16, 2021·Frontiers in Veterinary Science·Barbara Padalino, Laura Menchetti
Jul 17, 2020·Behavioural Brain Research·Annakarina MundorfNadja Freund
Feb 28, 2021·The European Journal of Neuroscience·Mijail Rojas-CarvajalJuan C Brenes
Mar 24, 2021·Brain Research Bulletin·Paula LunardiGrace S Pereira
Apr 13, 2021·Frontiers in Behavioral Neuroscience·Eden M AndersonMatthew Hearing
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Jeffrey S WilleyXiao Wen Mao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.