PMID: 16522271Mar 9, 2006Paper

Neurobiology of circadian rhythm sleep disorders

Current Neurology and Neuroscience Reports
Prasanth Manthena, Phyllis C Zee

Abstract

To adapt to a 24-hour environment, nearly all organisms, from mammals to single-celled organisms, have developed endogenous mechanisms that generate nearly 24-hour (circadian) rhythms in physiology and behavior, the most notable being that of the daily cycles of sleep and wake. Disruption of these circadian rhythms is often accompanied by disorders of sleep and wakefulness. With the recent advances in the molecular biology that underlies the development and maintenance of these rhythms, the pathophysiology behind circadian rhythm sleep disorders is becoming better understood.

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Citations

Oct 27, 2012·Neurologic Clinics·Alex Moszczynski, Brian James Murray
May 15, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jean-Christophe Leloup, Albert Goldbeter

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