Neurobiology of Propofol Addiction and Supportive Evidence: What Is the New Development?

Brain Sciences
Ming XiongAlex Bekker

Abstract

Propofol is a short-acting intravenous anesthetic agent suitable for induction and maintenance of general anesthesia as well as for procedural and intensive care unit sedation. As such it has become an unparalleled anesthetic agent of choice in many institutional and office practices. However, in addition to its idealistic properties as an anesthetic agent, there is accumulating evidence suggesting its potential for abuse. Clinical and experimental evidence has revealed that not only does propofol have the potential to be abused, but also that addiction to propofol shows a high mortality rate. Based on this evidence, different researchers have shown interest in determining the probability of propofol to be an addictive agent by comparing it with other drugs of abuse and depicting a functional similitude that involves the mesocorticolimbic pathway of addiction. In light of this, the Drug Enforcement Agency and the American Society of Anesthesiologists have put forth certain safety recommendations for the use of propofol. Despite this, the abuse potential of propofol has been challenged at different levels and therefore the preeminent focus will be to further validate the linkage from medicinal and occasional use of propofol to i...Continue Reading

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Citations

Mar 1, 2019·European Journal of Anaesthesiology·Philipp Lirk, James P Rathmell
Oct 24, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A Yu LubninG L Kobyakov
Dec 28, 2021·Anesthesia and Analgesia·Isao NagataYoshinori Kamiya

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