PMID: 2487156Nov 1, 1989Paper

Neuroblastoma consensus deletion maps to 1p36.1-2

Genes, Chromosomes & Cancer
A WeithM Schwab

Abstract

At least 70% of human neuroblastomas display cytogenetically visible aberrations in the short arm of chromosome 1. We have used a panel of probes detecting polymorphic DNA loci, most of which were derived from a library of microdissected distal 1p chromosome fragments, to compare the hybridization pattern of DNA on nine different tumors and the corresponding normal tissue. In eight of the neuroblastomas allelic loss was observed with at least two probes. The deletions were of different size. Since a consensus deletion in all eight tumors included the segment 1p36.1-2, we conclude that genetic information related to neuroblastoma tumorigenesis is located within this approximately 10 megabase segment. Previous studies have revealed the amplification of MYCN in neuroblastomas. Our study did not provide evidence for a correlation between MYCN amplification and the 1p deletion, suggesting that the two genetic alterations result from molecular mechanisms that are not directly related to each other.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C T FongG M Brodeur
Oct 9, 1987·Science·E R FearonB Vogelstein
Aug 1, 1988·British Journal of Cancer·A R Green
Feb 1, 1988·Cancer Genetics and Cytogenetics·E DontiP Cornaglia-Ferraris
Oct 23, 1987·Cell·H Donis-KellerE S Lander
Mar 25, 1985·Nucleic Acids Research·P G SealeyE M Southern

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Citations

Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·G SchleiermacherJ Michon
Aug 7, 1996·International Journal of Cancer. Journal International Du Cancer·J A KrausT Pietsch
Aug 1, 1996·Genes, Chromosomes & Cancer·M SchwabL C Amler
Sep 1, 1996·Genes, Chromosomes & Cancer·P PerriG P Tonini
Apr 25, 2001·Genes, Chromosomes & Cancer·N SpiekerR Versteeg
Jan 1, 1990·Genes, Chromosomes & Cancer·M Schwab, L C Amler
May 1, 1990·Genes, Chromosomes & Cancer·S BrüderleinM Schwab
Jan 1, 1992·Genes, Chromosomes & Cancer·R LundgrenF Mitelman
Aug 1, 1994·Genes, Chromosomes & Cancer·G SchleiermacherO Delattre
May 1, 1995·Genes, Chromosomes & Cancer·V L CrynsA Arnold
Dec 1, 1991·Cancer Metastasis Reviews·G M Brodeur, J F Moley
Jan 1, 1994·Breast Cancer Research and Treatment·L A CoxE Y Lee
Apr 25, 2000·Indian Journal of Pediatrics·S Shah, Y Ravindranath
Jan 1, 1997·Pathology Oncology Research : POR·Manfred Schwab
Sep 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Y MatsudaS Sakiyama
Feb 1, 1995·Cancer Genetics and Cytogenetics·W HennK D Zang
Feb 1, 1996·Cancer Genetics and Cytogenetics·H L ChenD S Chen
Jul 1, 1995·Cancer Genetics and Cytogenetics·D B ZimonjicJ A DiPaolo
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SchleiermacherO Delattre
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R VersteegN Van Roy
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M Brodeur
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Bénard
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L C AmlerM Schwab
Jan 1, 1994·Genetic Analysis, Techniques and Applications·C LengauerA Weith

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