Neuroblastoma messenger RNA is frequently detected in bone marrow at diagnosis of localised neuroblastoma patients

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Esther M van WezelGodelieve A M Tytgat

Abstract

The clinical importance of the detection of neuroblastoma messenger RNA (mRNA) in bone marrow (BM) of localised neuroblastoma patients at diagnosis remains unclear. In this prospective multicentre study, BM samples of a large cohort, were studied using real-time quantitative polymerase chain reaction (qPCR). BM samples at diagnosis from 160 patients with localised neuroblastoma were prospectively collected at Dutch and German centres between 2009 and 2013. qPCR was performed using five neuroblastoma specific markers. The association with other biological factors and the prognostic impact of BM positivity and clinical response was assessed. In 58 out of 160 patients neuroblastoma mRNA was detected in BM. In 47 of the 58 positive samples only one marker was found positive. BM positivity was significantly associated with MYCN amplification (p = 0.02) and deletion of chromosome 1p (p = 0.04). In total 31 patients had an event, of which only five patients had progression to stage IV. BM positivity was not associated with an unfavourable outcome. However, the detection of more than one marker was associated with an unfavourable outcome (systemic or local relapse) (event free survival 48% versus 85%; p = 0.03) in the whole cohort and ...Continue Reading

References

Jan 25, 1996·The New England Journal of Medicine·H CaronR Versteeg
Feb 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F BertholdP Weinel
Mar 1, 1997·Journal of Pediatric Hematology/oncology·G M BrodeurP S White
Oct 27, 2004·Clinical Chemistry·Karim HamaouiR Swaminathan
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Katrien SwertsKlaus Beiske
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel NavarroUNKNOWN European Study Group 94.01 Trial and Protocol
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara HeroFrank Berthold
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janine StutterheimGodelieve A M Tytgat
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tom MonclairUNKNOWN INRG Task Force
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan L CohnUNKNOWN INRG Task Force
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gudrun SchleiermacherOlivier Delattre
Dec 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hervé RubieJean Michon
Mar 25, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J StutterheimG A M Tytgat
Jun 28, 2011·Journal of Cancer Research and Clinical Oncology·Yania YáñezVictoria Castel
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janine StutterheimC Ellen van der Schoot
Jan 19, 2012·The Journal of Molecular Diagnostics : JMD·Janine StutterheimGodelieve A M Tytgat
Dec 3, 2014·The Journal of Molecular Diagnostics : JMD·Esther M van WezelGodelieve A M Tytgat
May 6, 2015·Pediatric Blood & Cancer·Esther M van WezelUNKNOWN GPOH MRD Study Group

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Citations

Jan 4, 2020·European Journal of Pediatrics·Ruben Van PaemelBram De Wilde
Jan 4, 2019·Journal of Cancer Research and Clinical Oncology·Alexander PopovLarisa Fechina
Jun 20, 2019·Frontiers in Oncology·Suguru UemuraNoriyuki Nishimura
Jun 1, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Araz MarachelianRobert C Seeger

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