PMID: 9554539Apr 29, 1998Paper

Neuroblastoma screening in the United States: results of the Texas Outreach Program for neuroblastoma screening

Cancer
J L AterW A Bleyer

Abstract

Mass screening of infants for neuroblastoma began in Japan after studies suggested that survival rates could be improved by early detection. This study was initiated in 1991 to test the methodology and feasibility of screening for neuroblastoma within the U. S. health care system. Infants ages 5-10 months (mean age, 9 months, 25 days) who were born in Texas were screened for neuroblastoma. An enzyme-linked immunoadsorbent assay (ELISA) for homovanillic acid (HVA) and vanillylmandelic acid (VMA) used to quantify the HVA and VMA was performed on urine extracted from specimens dried on filter paper. Infants were recruited to participate in the study by several methods, and the effectiveness of each method was determined by calculating compliance rates. Between February 1991 and June 1994 a total of 14,046 infants were recruited to participate in neuroblastoma screening. Neuroblastoma was detected in 2 children for an incidence rate of 1 in 7023. A total of 291,158 screening kits were distributed to the parents of these infants, resulting in an overall compliance rate of only 4.8%. Compliance rates varied by method of distribution of the test kits: Houston Women, Infants, and Children (WIC) clinic (53%), volunteers (31%), Rio Grand...Continue Reading

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Citations

Jun 1, 2000·Cellular Immunology·R GökeY Chen
Oct 18, 2000·Biochemical and Biophysical Research Communications·I K KimY K Jung
Apr 5, 2002·The New England Journal of Medicine·William G WoodsBernard Lemieux
Nov 21, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·T Manickum
Sep 24, 1999·Medical and Pediatric Oncology·W G WoodsB Lemieux
Jan 25, 2003·Journal of Pediatric Hematology/oncology·Gabriele DobrovoljskiHerwig Lackner

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