Abstract
A 5-month-old, female, Aberdeen Angus heifer presented to the veterinary medical teaching hospital for evaluation of slowly progressive hindlimb ataxia. The calf was clinically normal until 4 months of age, following routine pregnancy and delivery. Neurologic examination revealed marked symmetric spastic hindlimb paraparesis. Thoracolumbar radiographs and cerebrospinal fluid (CSF) analysis were unremarkable. A presumptive diagnosis of T3-L3 myelopathy was made, and neurologic status remained static for 3 months with broad-spectrum antibiotic and nonsteroidal anti-inflammatory therapy. Additional diagnostic tests were refused, and a necropsy was performed following euthanasia. A moderately well delineated, reddish-tan, soft mass 18 mm in diameter replaced 80% of the fourth lumbar spinal cord segment. Histologic examination revealed two distinct features: undifferentiated, primitive, polygonal-to-round cells with typical morphologic characteristics of primitive neuroectoderm; and interspersed areas containing myelinated axons and cells with neuronal differentiation. Immunohistochemical examination confirmed the presence of primitive neuroepithelium and cells with neuronal differentiation.
References
Jan 1, 1975·Veterinary Pathology·R Cimprich, P Ardington
Oct 1, 1992·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·C LoudenG E Sandusky
Aug 1, 1991·Journal of Comparative Pathology·J Martin de las MulasM A Sierra
Mar 1, 1987·Veterinary Pathology·L RothC A Stanton
Oct 1, 1973·Australian Veterinary Journal·B L MundayR Cumming
Nov 1, 1984·Veterinary Pathology·J S Haynes, J R Leininger
Jul 12, 1980·The Veterinary Record·J R Baker, I S Kippax
May 1, 1995·Journal of Neuropathology and Experimental Neurology·K M Fung, J Q Trojanowski
Jul 1, 1994·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D Y KimD G Luther
Jul 1, 1994·Journal of Comparative Pathology·K OmiK Kadota
Dec 24, 1997·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·L J ForrestE G MacEwen
Aug 26, 1998·The Journal of Veterinary Medical Science·K UchidaS Tateyama
Dec 24, 1998·Toxicologic Pathology·S MatsushimaM Torii
Citations
Jan 18, 2014·Journal of the American Veterinary Medical Association·Kristin M PattonHoward B Gelberg
Feb 9, 2012·Avian Diseases·O DezfoulianK Kiani
Jan 25, 2014·Journal of Comparative Pathology·A M Arenas-GamboaR Storts
May 20, 2008·Veterinary Pathology·R UlrichA Beineke
May 1, 2010·The Journal of Veterinary Medical Science·Yasutsugu MiwaNobuo Asaki
Apr 12, 2019·The Journal of Veterinary Medical Science·Yusuke SakaiMasahiro Morimoto