PMID: 8959048Oct 31, 1996Paper

Neurochemical analysis of the psychotoxicity of methamphetamine and cocaine by microdialysis in the rat brain

Annals of the New York Academy of Sciences
A ShimadaT Yanagita

Abstract

To examine the neurochemical mechanism underlying the development of psychotoxicity by methamphetamine and cocaine, the levels of dopamine, serotonin and their metabolites were determined by in vivo microdialysis in the brains of freely moving rats. Methamphetamine (0.5 mg/kg, s.c.) or cocaine (10 mg/kg, i.p.) was repeatedly administered for 8 to 21 experiment days, and after confirming the development of sensitization to the stimulating effect of the drugs on spontaneous motor activity, a microdialysis probe was implanted into the nucleus accumbens (N.Acc.) or striatum of the brain of the treated rats. Then, each test drug was readministered to the rats and dopamine and DOPAC or serotonin and 5-HIAA concentrations were determined. In the N.Acc. of untreated control rats, methamphetamine increased dopamine to about 4 times the preadministration value along with a decrease of DOPAC. Methamphetamine also increased serotonin to about twice the preadministration value along with no change in 5-HIAA. Cocaine increased dopamine to about 4 times along with a slight decrease in DOPAC. In the treated rats as compared with the untreated rats, the increasing effect of methamphetamine on dopamine in the N.Acc. was enhanced but that of coca...Continue Reading

References

Jan 1, 1976·European Journal of Pharmacology·A J PijnenburgJ M Van Rossum
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 1, 1983·Psychological Medicine·G D Ellison, M S Eison

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Citations

Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin D LominacTod E Kippin
May 10, 2011·Pharmacology, Biochemistry, and Behavior·Keith A TrujilloMelissa M Guaderrama
Jun 15, 2010·Drug and Alcohol Dependence·Katsutoshi ShiodaSatoshi Kato
Jul 14, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vera Bubenikova-ValesovaRomana Slamberova
Feb 19, 2010·Toxicology Mechanisms and Methods·Minori NishiguchiHajime Nishio

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