Abstract
Quinolinic acid (QUIN) is an endogenous excitatory amino acid, which is elevated in brain tissues or cerebrospinal fluid (CSF) in several acute and chronic inflammatory central nervous system (CNS) diseases. The functional significance of this elevation is unknown but speculations of excitotoxicity have been raised. We have begun to address the pathologic consequences of elevated CSF QUIN by studying the effects of intracerebroventricular (i.cv) administration of QUIN on regional choline acetyltransferase (ChAT) activity, somatostatin content and glucose metabolism in the rat brain. QUIN (12 and 60 nmol) i.cv administration once a day for 7 days (total dose; 84 and 420 nmol, respectively) had minimal effect on somatostatin content and no effect on ChAT activity. In contrast, following continuous i.cv infusion of QUIN for 14 days using an osmotic minipump (480 nmol), ChAT activity dropped in the hippocampus and the striatum and somatostatin content was reduced in the frontal cortex, hippocampus, striatum and amygdala. Moreover, following the QUIN infusion, glucose utilization decreased in the basal nucleus of Meynert, frontal cortex, and portions of the basal ganglia and the limbic system. These results indicate that subchronic ...Continue Reading
References
Feb 16, 1978·Nature·J V NadlerC W Cotman
May 1, 1977·Journal of Neurochemistry·L SokoloffM Shinohara
Jul 10, 1992·Brain Research·H W BoddekeJ M Palacios
Jan 1, 1992·Neurology·J J Halperin, M P Heyes
Mar 1, 1990·Journal of Neurochemistry·M P HeyesR N Auer
Feb 1, 1991·Annals of Neurology·M P HeyesJ Keilp
Jan 2, 1991·Neuroscience Letters·Z SuselT N Chase
Jan 28, 1991·Neuroscience Letters·M P HeyesM F Beal
Oct 2, 1990·Neuroscience Letters·K YamadaT Kameyama
May 8, 1986·Nature·M F BealJ B Martin
Dec 1, 1986·Journal of Neurochemistry·F MoroniN P Nair
Feb 27, 1989·Neuroscience Letters·W O Whetsell, R Schwarcz
Aug 1, 1989·Annals of Neurology·M P HeyesS P Markey
Apr 22, 1988·Neuroscience Letters·R BalázsO S Jørgensen
Feb 5, 1986·Nature·R G MorrisM Baudry
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R SchwarczW O Whetsell
Jun 17, 1985·Brain Research·A C FosterR Schwarcz
Jul 9, 1987·European Journal of Pharmacology·C A TammingaT N Chase
Jan 1, 1971·Experimental Brain Research·J W OlneyV Rhee
Jun 1, 1971·Journal of Neurochemistry·G Bull, B Oderfeld-Nowak
Nov 20, 1980·Nature·P DaviesR D Terry
Jul 1, 1981·Endocrinology·H AbeT Fujita
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Jul 15, 1983·Neuroscience Letters·R Schwarcz, C Köhler
Nov 11, 1983·Neuroscience Letters·M WolfensbergerR Schwarcz
Jan 21, 1983·Science·R SchwarczR M Mangano
Sep 1, 1994·Experimental Neurology·G Figueredo-CardenasA Reiner
Apr 1, 1993·Experimental Neurology·T J BazzettR L Albin
May 28, 1993·Annals of the New York Academy of Sciences·M P Heyes
Jun 1, 1993·The Journal of Clinical Investigation·C L AchimC A Wiley
Apr 1, 1963·The Journal of Physiology·D R CURTIS, J C WATKINS