Jan 19, 2019

Neurochemical and molecular mechanisms underlying the retrieval-extinction effect

Psychopharmacology
Emma N Cahill, Amy L Milton

Abstract

Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.

  • References177
  • Citations2

Mentioned in this Paper

Research
Fear (Mental Process)
Extinction, Psychological
Neurotransmitters
Signal Pathways
Intracellular
Dopamine Receptor
N-Methyl-D-Aspartate Receptors
Recovery - Healing Process
Receptor

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