Neurochemical and Neuroendocrine Effects of Ibogaine in Rats: Comparison to MK-801

Annals of the New York Academy of Sciences
M H BaumannSyed F Ali

Abstract

Ibogaine (IBO) is a naturally-occurring indole compound that is being evaluated as a potential medication for substance use disorders. Although the precise mechanism of IBO action is unclear, recent in vitro data show this drug displays properties similar to the noncompetitive N-methyl-d-aspartate (NMDA) antagonist MK-801. The purpose of the present work was to compare In Vivo neurobiological effects of IBO and MK-801 in rats. Groups of male rats (n = 6-8/group) were decapitated 30 and 60 min after receiving intraperitoneal (i.p.) IBO (10 & 100 mg/kg), MK-801 (0.1 & 1.0 mg/kg) or vehicle. Trunk blood was collected for the analysis of plasma prolactin and corticosterone; brains were harvested and dissected for determination of dopamine (DA), serotonin (5-HT) and their metabolites. Both IBO and MK-801 increased corticosterone secretion, but only IBO elevated plasma prolactin. IBO produced dramatic reductions in tissue DA levels with concurrent increases in the metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This profile of IBO-induced changes in DA transmission was observed in the striatum, olfactory tubercle, and hypothalamus. The effects of MK-801 on DA metabolism did not mimic IBO, as MK-801 tended...Continue Reading

References

Jan 1, 1992·Life Sciences·H SershenA Lajtha
Apr 3, 1991·European Journal of Pharmacology·S D GlickJ N Carlson
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P V PiazzaH Simon
Jan 1, 1991·Annual Review of Pharmacology and Toxicology·L D Van de Kar
Jan 1, 1989·Life Sciences·R KarlerS A Turkanis
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Nov 4, 1988·Science·G F Koob, F E Bloom
Jun 6, 1995·European Journal of Pharmacology·W D BowenA E Jacobson
Jan 1, 1995·Life Sciences·R H MachS R Childers
Jul 1, 1994·Journal of Substance Abuse Treatment·S G Sheppard
Sep 14, 1993·European Journal of Pharmacology·S L Cappendijk, M R Dzoljic
Nov 2, 1993·European Journal of Pharmacology·M D Schechter, T L Gordon
Feb 9, 1993·European Journal of Pharmacology·P H WuH Kalant
Apr 1, 1996·Neuropharmacology·K ChenM A Rogawski

❮ Previous
Next ❯

Citations

May 7, 2002·Canadian Journal of Physiology and Pharmacology·Frédéric CaniniLionel Bourdon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.