PMID: 9531443Apr 8, 1998Paper

Neurochemical characterization and distribution of enteric GABAergic neurons and nerve fibres in the human colon

Journal of the Autonomic Nervous System
A KrantisW Staines

Abstract

GABA, somatostatin and enkephalin are neurotransmitters of enteric interneurons and comprise part of the intrinsic neural circuits regulating peristalsis. Within the relaxation phase of reflex peristalsis, nitric oxide (NO) is released by inhibitory motor neurons and perhaps enteric interneurons as well. Previously, we identified by GABA transaminase (GABA-T) immunohistochemistry, a subpopulation of GABAergic interneurons in the human colon which also contain NO synthase activity and hence produce NO. In this study, we have examined further the capacity for cotransmission within the GABAergic innervation in human colon. The expression of two important neuropeptides within GABAergic neurons was determined by combined double-labelled immunocytochemistry using antibodies for GABA-T, enkephalin and somatostatin, together with the demonstration of NO synthase-related NADPH diaphorase staining in cryosectioned colon. Both neuropeptides were found in GABAergic neurons of the colon. The evidence presented herein confirms the colocalization of NO synthase activity and GABA-T immunoreactivity in subpopulations of enteric neurons and further allows the neurochemical classification of GABAergic neurons of the human colon into three subsets...Continue Reading

References

Dec 15, 1992·European Journal of Pharmacology·A CalignanoS Moncada
Jun 15, 1991·Journal of the Autonomic Nervous System·A Krantis, D Clark
Dec 16, 1985·Life Sciences·C Tanaka
Jun 1, 1980·The Journal of Physiology·Y Katayama, R A North
Jan 1, 1984·Cell and Tissue Research·J R KeastM Costa
May 1, 1984·British Journal of Pharmacology·E Cherubini, R A North
Aug 1, 1983·The Journal of Comparative Neurology·T NagaiE G McGeer
Nov 11, 1982·Brain Research·S R VincentE G McGeer
Jun 25, 1995·Journal of the Autonomic Nervous System·A KrantisW Staines
Aug 1, 1993·Journal of the Autonomic Nervous System·B I Gustafsson, D S Delbro
May 1, 1994·Journal of the Autonomic Nervous System·A KrantisG P Morris
May 23, 1994·European Journal of Pharmacology·B I Gustafsson, D S Delbro
Sep 15, 1993·The Journal of Comparative Neurology·R C SpikeH M Johnston
Aug 1, 1993·Neurochemistry International·L H TsaiJ Y Wu

❮ Previous
Next ❯

Citations

Mar 19, 2005·Histochemistry and Cell Biology·A BrehmerH Rupprecht
Nov 17, 2009·Histochemistry and Cell Biology·Axel BrehmerWinfried Neuhuber
Mar 30, 1999·European Journal of Pharmacology·N PenchevaP Milanov
Dec 17, 2002·Current Opinion in Pharmacology·John B Furness, Gareth J Sanger
Oct 7, 2006·Current Opinion in Gastroenterology·J R Grider, A E Foxx-Orenstein
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Schemann, M Neunlist
Sep 22, 2006·Cell Proliferation·I R Radford, P N Lobachevsky
May 24, 2006·Neuroscience Letters·Jung Cheol ParkByung Pil Cho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.