PMID: 6110209Jan 1, 1981Paper

Neurochemical consequences following administration of CNS stimulants to the neonatal rat

Pharmacology, Biochemistry, and Behavior
G C WagnerL S Seiden

Abstract

The possible induction of long-lasting catecholamine depletions in discrete brain regions by psychomotor stimulant drugs was examined in neonatal rats. Three agents, methylamphetamine, d-amphetamine, and methylphenidate were administered to groups of rat pups from days 10 to 40 of life. Pups were killed 2 weeks beyond the last drug administration. Catecholamine levels of various brain regions from groups of rats receiving 12.5, 25 or 50 mg/kg/day of each drug were compared with levels of vehicle treated pups. Both methylamphetamine and d-amphetamine at the higher doses induced long-lasting dopamine depletions in the caudate of rat pups. Methylphenidate had no long-term effect on dopamine while norepinephrine levels were not altered by any treatment.

References

Jul 1, 1978·Pharmacology, Biochemistry, and Behavior·A G Nasello, O A Ramirez
Sep 1, 1979·Drug and Alcohol Dependence·G C WagnerC R Schuster
Feb 1, 1976·Drug and Alcohol Dependence·L S SeidenC R Schuster
Apr 1, 1981·Pharmacology, Biochemistry, and Behavior·S E BittnerL S Seiden
Dec 1, 1964·International Journal of Neuropharmacology·C C CHANG

❮ Previous
Next ❯

Citations

Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G C Wagner, S L Walsh
Mar 1, 1996·Neurotoxicology and Teratology·K D Acuff-SmithC V Vorhees
Feb 1, 2002·European Journal of Pharmacology·Evan L RiddleAnnette E Fleckenstein
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·V ArmstrongS A McDougall
Dec 13, 2000·Brain Research. Brain Research Reviews·D O Frost, J L Cadet
Jan 14, 1998·Brain Research. Developmental Brain Research·G D CapponC V Vorhees
Mar 29, 2001·Neurotoxicology and Teratology·G D Cappon, C V Vorhees
Aug 14, 2008·Molecular Psychiatry·S M BermanE D London
Aug 19, 2014·Neurotoxicology and Teratology·John J PanosSherry A Ferguson
Aug 2, 2003·Journal of Pharmacological Sciences·Taizo KitaToshikatsu Nakashima
Sep 17, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mari GolubMary Vore
Aug 30, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mari GolubMary Vore
Feb 22, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cynthia V RiderJane Ellen Simmons
Oct 23, 2012·International Journal of Experimental Pathology·Paulina KazmierskaJan Konopacki
Oct 18, 2000·Journal of Neurochemistry·J M KokoshkaG R Hanson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.