Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdialysis

Brain Research
M MasJ L Gonzalez-Mora

Abstract

The extracellular levels of the dopamine (DA) metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the medial preoptic area (MPOA) of male rats were monitored during unrestricted copulation, the ensuing state of sexual refractoriness and the resumption of mating activity. MPOA dialysates were collected from the same animal during four consecutive days. In the first day the subjects were allowed to copulate until reaching a satiation criterion. That was associated with a marked increase in the dialysate levels of the three metabolites assessed. During the next two days the animals remained sexually inactive when exposed to receptive females. Their basal levels of DOPAC and HVA were elevated, whereas those of 5-HIAA remained as low as in the first session. During the non-mating exposure to receptive females there were only minor changes in the three metabolites. By the fourth day, just before the animals resumed copulation, the basal levels of the DA metabolites, especially HVA, had decreased to values closer to those found in the first day. When they mated again to exhaustion the levels of DOPAC, HVA, and 5-HIAA increased as in the first se...Continue Reading

Citations

Jan 25, 2003·The European Journal of Neuroscience·P F FerrariK A Miczek
Nov 26, 2009·Archives of Sexual Behavior·Martin P Kafka
Jan 24, 2017·The Journal of Clinical Investigation·Alexander N ComninosWaljit S Dhillo
Aug 14, 2003·Scandinavian Journal of Psychology·Alonso Fernández-Guasti, Gabriela Rodríguez-Manzo
Jul 2, 2008·Annals of the New York Academy of Sciences·Marisela Hernández-GonzálezAnders Agmo
May 22, 2018·Sexual Abuse : a Journal of Research and Treatment·Wineke J Smid, Edwin C Wever
Jul 1, 2017·The AAPS Journal·Alexander G Zestos, Robert T Kennedy
Sep 1, 2015·Physiology & Behavior·Jorge Rojas-Hernández, Jorge Juárez

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