Neurochemical effects of chronic co-administration of ritanserin and haloperidol: comparison with clozapine effects

European Journal of Pharmacology
J LappalainenE Syvälahti

Abstract

The effects of chronic treatment with clozapine (20 mg/kg per day), ritanserin (0.5 mg/kg per day), haloperidol (0.5 mg/kg per day), or the combination of haloperidol and ritanserin, on dopamine (DA) and serotonin (5-HT) metabolism were studied. Chronic haloperidol treatment decreased DA metabolism in nucleus caudatus. Chronic ritanserin treatment failed to alter striatal or mesolimbic DA metabolism but decreased the concentrations of 5-HT and 5-hydroxyindoleacetic acid in the nucleus raphe dorsalis. The effects of chronic haloperidol were not altered by concomitant ritanserin administration. In comparison, chronic clozapine treatment affected neither DA nor 5-HT metabolism. These results show that the biochemical effects of chronic haloperidol treatment on the major ascending DA neurons cannot be modulated by concomitant 5-HT2 receptor blockade.

Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·M L Wadenberg
Mar 1, 1996·Psychopharmacology·B J Kinon, J A Lieberman
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·M L Wadenberg
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·W KoekF C Colpaert

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