Neurochemical factors underlying individual differences in locomotor activity and anxiety-like behavioral responses in zebrafish

Progress in Neuro-psychopharmacology & Biological Psychiatry
Steven TranRobert Gerlai

Abstract

Variation among individuals may arise for several reasons, and may have diverse underlying mechanisms. Individual differences have been studied in a variety of species, but recently a new model organism has emerged in this field that offers both sophistication in phenotypical characterization and powerful mechanistic analysis. Recently, zebrafish, one of the favorites of geneticists, have been shown to exhibit consistent individual differences in baseline locomotor activity. In the current study, we further explore this finding and examine whether individual differences in locomotor activity correlate with anxiety-like behavioral measures and with levels of dopamine, serotonin and the metabolites of these neurotransmitters. In addition, we examine whether individual differences in locomotor activity are also associated with reactivity to the locomotor stimulant effects of and neurochemical responses to acute ethanol exposure (30min long, 1% v/v ethanol bath application). Principal component analyses revealed a strong association among anxiety-like responses, locomotor activity, serotonin and dopamine levels. Furthermore, ethanol exposure was found to abolish the locomotion-dependent anxiety-like behavioral and serotonergic resp...Continue Reading

References

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Oct 7, 2014·Pharmacology, Biochemistry, and Behavior·Magda NowickiRobert Gerlai

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Citations

Jan 17, 2017·Zebrafish·Steven TranRobert Gerlai
Feb 18, 2016·Psychopharmacology·Steven TranRobert Gerlai
Sep 19, 2018·Scientific Reports·Débora FiorLeonardo José Gil Barcellos
Feb 24, 2017·PeerJ·Adrian Johnson, Trevor James Hamilton
Dec 18, 2020·Biological Reviews of the Cambridge Philosophical Society·Viacheslav V KrylovElena A Osipova
Feb 6, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Krishan AriyasiriCheol-Hee Kim
Jun 15, 2021·Journal of Biomolecular Structure & Dynamics·Antonio Wlisses da SilvaEmmanuel Silva Marinho

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