Jan 5, 2002

Neurochemical findings in the MPTP model of Parkinson's disease

Journal of Neural Transmission
N Schmidt, B Ferger

Abstract

Animal models are a very important approach to study the pathogenesis and therapeutic intervention strategies of human diseases. Since many human disorders do not arise spontaneously in animals, characteristic functional changes have to be mimicked by neurotoxic agents. For instance, the application of the dopaminergic neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is able to produce striking similarities to Parkinson's disease (PD) diagnosed in humans. MPTP is thought to selectively damage dopaminergic neurons predominantly those originating in the substantia nigra pars compacta (SNc) which leads to impaired dopaminergic neurotransmission accompanied by a loss of dopaminergic nerve terminals in the striatum. MPTP-induced neurochemical, behavioral, and histopathological alterations replicate very closely the clinical symptoms of PD patients, which will be discussed in this paper and render the MPTP model currently the most favored PD model to study therapeutic intervention strategies in an easy and reliable way in preclinical studies. We and many other research groups propose that the knowledge about the neurotoxic mechanisms of MPTP such as mitochondrial dysfunction with breakdown of energy metabolism and free ...Continue Reading

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Mentioned in this Paper

Pars Compacta
Pathogenic Aspects
MPTP-Induced Degeneration of the Striatum
Behavior, Animal
Pathogenesis
Neostriatum
Reactive Nitrogen Species
Energy Metabolism
Free Radicals
Synaptic Transmission

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