Neurochemical heterogeneity of the primate nucleus accumbens

Experimental Brain Research
K IkemotoH C Fibiger

Abstract

In order to further investigate the neurochemical anatomy of the primate nucleus accumbens (NAC), the distributions of the neuropeptides leucine-enkephalin (Leu-ENK), neurotensin (NT), and substance P (SP) and of haloperidol-induced c-fos expression were investigated in the macaque monkey using immunohistochemical methods. To define the boundaries of the NAC, dopamine (DA) and tyrosine hydroxylase (TH) immunohistochemistry was performed. In addition, to formulate the distinction between subdivisions of the nucleus accumbens, immunohistochemistry for calbindin-D28 (CBD) and SP was employed. In general, the medial part of NAC, which consisted of small to medium-sized cells, was low for CBD immunoreactivity and moderate to high for SP immunoreactivities, while the dorsolateral part, which was composed of small cells, showed the opposite pattern of immunostaining for CBD and SP. Many Leu-ENK-immunoreactive perikarya were observed in the dorsal NAC at its middle and caudal levels. There were moderate densities of Leu-ENK-positive fibers throughout the medial part of the NAC. At the dorsolateral margin of the NAC, Leu-ENK-positive fibers formed patches. Most NT-positive perikarya were found in the dorsolateral subdivision. SP-positiv...Continue Reading

Citations

Nov 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·K IkemotoK Satoh
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·C A HeidbrederJ Feldon
Aug 29, 1997·Neuroscience Letters·K IkemotoI Nagatsu
Jan 1, 1997·Brain Research Bulletin·K Ikemoto
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Jul 23, 1999·Annals of the New York Academy of Sciences·S N Haber, N R McFarland
Apr 17, 2015·Annals of the New York Academy of Sciences·Kalynda K Gonzales, Yoland Smith
Mar 31, 2015·Schizophrenia Bulletin·Lesley A McCollumRosalinda C Roberts
Apr 24, 1999·The European Journal of Neuroscience·S SatohO Hayaishi
Nov 28, 2002·The Journal of Comparative Neurology·Todd Freeman RobertsSteven Earle Brauth

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