Abstract
Trypanosoma brucei brucei (TREU 667) infected mice were used as a model of African trypanosomiasis, a disease in which neuropsychiatric manifestations occur. To study the possible neurochemical basis of these abnormalities, we measured brain acetylcholine receptor numbers, activities of the cholinergic enzymes, choline acetyltransferase (CAT), and acetylcholinesterase (AChE), and regional concentrations of the monoamines, dopamine (DA), serotonin (5-HT), and norepinephrine (NE), and their acid metabolites, homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) in mice infected with T. b. brucei. There were no significant changes in CAT or AChE activities or acetylcholine receptor numbers at either 35 or 50 days post-infection (PI). At day 35 PI, the only significant finding was a decrease in 5-HIAA concentration in the brain stem, a change which did not persist to day 50 PI. At day 50 PI there were, however, significant increases in DA concentration in the brain stem and NE concentrations in the hippocampus, cerebellum, brain stem and striatum. To establish a chronic relapsing murine model, mice were treated with diminazene aceturate (Berenil) at day 60 PI and killed 60 days lat...Continue Reading
References
Mar 15, 1975·Experientia·H H Stibbs, J R Seed
Aug 1, 1979·International Journal for Parasitology·F W JenningsG M Urquhart
Oct 1, 1977·Parasitology·F W JenningsG M Urquhart
Apr 28, 1978·Science·I J FarleyO Hornykiewicz
Apr 1, 1975·The Journal of Infectious Diseases·H H Stibbs, J R Seed
Dec 1, 1987·Annals of Tropical Medicine and Parasitology·H H Stibbs, D A Curtis
May 1, 1985·The American Journal of Tropical Medicine and Hygiene·D J BrennesselH B Tanowitz
Feb 1, 1985·The American Journal of Psychiatry·R B OstroffJ Mason
Dec 1, 1985·Experimental Parasitology·B O AmoleH B Tanowitz
Dec 1, 1973·Experientia·H H Stibbs, J R Seed
Nov 1, 1969·The Biochemical Journal·F Fonnum
Jan 1, 1966·Acta Psychiatrica Scandinavica·T A Lambo
Jun 1, 1981·Archives of General Psychiatry·L TräskmanL Sjöstrand
Nov 1, 1984·Journal of Neurochemistry·H H Stibbs
Mar 1, 1983·The Journal of Infectious Diseases·H B TanowitzM Wittner
Apr 1, 1981·Experimental Parasitology·H B TanowitzM Wittner
Oct 7, 1982·Nature·O Hornykiewicz
Jul 20, 1981·Brain Research·P Davies, S Feisullin
Citations
Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·V W Pentreath
Feb 1, 1997·Experimental Parasitology·M KeitaM Dumas
Sep 29, 2009·Research in Veterinary Science·A S Da SilvaS G Monteiro
Nov 3, 2010·Experimental Parasitology·Aleksandro S Da SilvaSonia T A Lopes