Neurochemical measurements in the brains of mice infected with Trypanosoma brucei brucei (TREU 667).

Annals of Tropical Medicine and Parasitology
B AmoleH B Tanowitz

Abstract

Trypanosoma brucei brucei (TREU 667) infected mice were used as a model of African trypanosomiasis, a disease in which neuropsychiatric manifestations occur. To study the possible neurochemical basis of these abnormalities, we measured brain acetylcholine receptor numbers, activities of the cholinergic enzymes, choline acetyltransferase (CAT), and acetylcholinesterase (AChE), and regional concentrations of the monoamines, dopamine (DA), serotonin (5-HT), and norepinephrine (NE), and their acid metabolites, homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) in mice infected with T. b. brucei. There were no significant changes in CAT or AChE activities or acetylcholine receptor numbers at either 35 or 50 days post-infection (PI). At day 35 PI, the only significant finding was a decrease in 5-HIAA concentration in the brain stem, a change which did not persist to day 50 PI. At day 50 PI there were, however, significant increases in DA concentration in the brain stem and NE concentrations in the hippocampus, cerebellum, brain stem and striatum. To establish a chronic relapsing murine model, mice were treated with diminazene aceturate (Berenil) at day 60 PI and killed 60 days lat...Continue Reading

References

Aug 1, 1979·International Journal for Parasitology·F W JenningsG M Urquhart
Apr 1, 1975·The Journal of Infectious Diseases·H H Stibbs, J R Seed
Dec 1, 1987·Annals of Tropical Medicine and Parasitology·H H Stibbs, D A Curtis
May 1, 1985·The American Journal of Tropical Medicine and Hygiene·D J BrennesselH B Tanowitz
Feb 1, 1985·The American Journal of Psychiatry·R B OstroffJ Mason
Dec 1, 1985·Experimental Parasitology·B O AmoleH B Tanowitz
Jun 1, 1981·Archives of General Psychiatry·L TräskmanL Sjöstrand
Mar 1, 1983·The Journal of Infectious Diseases·H B TanowitzM Wittner

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