PMID: 9423929Jan 10, 1998Paper

Neurochemical mechanisms of nitroglycerin-induced neuronal activation in rat brain: a pharmacological investigation

Neuropharmacology
C TassorelliG Nappi

Abstract

Nitroglycerin is a nitric oxide donor which induces sustained expression of Fos protein, a marker of neuronal activation, in specific neuronal groups in the central nervous system. The mechanisms which underlie nitroglycerin-induced neuronal activation are elusive at this time, although a precise role has been suggested for the pool of neurons containing nitric oxide synthase as well as for catecholaminergic and peptidergic pathways. The aim of this study was to provide further details on the central effect of nitroglycerin by means of a pharmacological manipulation of nitroglycerin-induced neuronal activation with inhibitors of the nitric oxide synthase, modulators of the sympathetic drive and mediators of pain perception. Adult male Sprague-Dawley rats received L-NGnitro-arginine methyl ester, 7-nitro-indazole, ephedrine sulfate, indomethacin, capsaicin or vehicle before the subcutaneous injection of nitroglycerin (10 mg/kg b.w.). They were sacrificed 4 hr after nitroglycerin administration and brain sections were processed for immunocytochemical visualization of Fos. All the pharmacological treatments administered before injecting nitroglycerin selectively influenced Fos expression in the different brain nuclei. The data obt...Continue Reading

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Citations

Jun 6, 2002·Cephalalgia : an International Journal of Headache·C TassorelliG Nappi
Apr 18, 2003·Cephalalgia : an International Journal of Headache·M G BuzziG Nappi
Jan 20, 2004·Cephalalgia : an International Journal of Headache·G SancesG Nappi
Jun 16, 2010·Headache·Geoffrey A Lambert
May 14, 2014·Expert Opinion on Investigational Drugs·Piero BarbantiDavid Della-Morte
Mar 2, 2006·European Journal of Pharmacology·Cristina TassorelliGiuseppe Nappi
Oct 30, 2015·Cephalalgia : an International Journal of Headache·Gábor Nagy-GróczÁrpád Párdutz
Feb 19, 2011·The Journal of Headache and Pain·Rosaria GrecoCristina Tassorelli
Sep 19, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nastaren AbadSamuel C Grant
Jun 17, 2010·Pharmaceuticals·Arpad Pardutz, Jean Schoenen

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