Neurochemically distinct myenteric neurone populations containing calbindin have specific distribution patterns around the circumference of the gastric corpus

Cell and Tissue Research
D ReicheM Schemann

Abstract

We recently described calbindin immunoreactivity in the myenteric plexus of the guinea-pig stomach. To study the neurochemical coding of calbindin D28 k (CALB)-containing myenteric neurones, the presence of calretinin (CALRET), choline acetyltransferase (ChAT), enkephalin (ENK), neuropeptide Y, serotonin (5-HT), somatostatin (SOM) and substance P(SP) was investigated immunohistochemically in colchicine-treated preparations. Nitric oxide synthase-containing neurones were detected by NADPH-diaphorase histochemistry. In addition, we investigated the neurone distribution patterns around the gastric corpus. Most CALB neurones were ChAT positive. ChAT/CALB neurones were either CALRET (ca 75%) or 5-HT positive and most contained in addition SP and/or ENK. All 5-HT neurones contained CALB. CALB labelled on average 2.3, 4.8 and 7.5 neurones per ganglion at the lesser curvature, in the central region and the greater curvature, respectively, which indicated a preferential localisation at the greater curvature. Compared to the total number of myenteric neurones, the proportion of CALB neurones increased significantly from the lesser curvature (6%) towards the greater curvature (18%). This shift, although observed for most ChAT/CALB-positiv...Continue Reading

Citations

Jan 1, 2012·Scientifica·Klaus Bielefeldt
Aug 3, 2010·Autonomic Neuroscience : Basic & Clinical·Catharina Olsson
Nov 19, 2015·Frontiers in Cellular Neuroscience·Gemma Mazzuoli-Weber, Michael Schemann
Jun 1, 2011·Journal of Animal Physiology and Animal Nutrition·H PfannkucheG Gäbel
Sep 21, 2010·The Journal of Comparative Neurology·Leen UyttebroekLuc Van Nassauw
Jan 28, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Oct 11, 2005·Autonomic Neuroscience : Basic & Clinical·Kiyoshi TsukamotoTakehira Yamamura
May 31, 2007·Memory & Cognition·Peter Ward, Patrick Sturt
Mar 20, 2019·The EMBO Journal·Bénédicte OulèsFiona M Watt
Sep 13, 2019·International Journal of Molecular Sciences·Slawomir Gonkowski, Liliana Rytel

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