Abstract
Introduction: Synthetic cannabinoid mixtures have been easily accessible for years, leading to the belief that these products were natural and harmless, which contributed to their popularity. Nevertheless, there are many reports of users ending up in hospital due to severe side effects such as tachycardia, aggression, and psychosis. Controlled studies on the effects of synthetic cannabinoids on human performance are lacking. In the present study, we assessed the safety pharmacology of the synthetic cannabinoid JWH-018 after acute administration. Methods: Seventeen healthy cannabis-experienced participants took part in this placebo-controlled, crossover study. Participants inhaled the vapor of JWH-018 (doses ranged between 2 and 6.2 mg) and were subsequently monitored for 12 h, during which vital signs, cognitive performance, and subjective experience were measured. Subjective high scores showed that there is a large variability in the subjective experience of participants. Therefore, a mixed analysis of variance, with "Responder" (i.e., subjective high score >2) as a between-subjects factor and "Drug" as a within-subjects factor (placebo and JWH-018), was used. Results: Serum concentrations of JWH-018 were significantly higher ...Continue Reading
References
Aug 22, 1973·Psychopharmacologia·J VolavkaM Fink
Jan 1, 1981·Psychopharmacology·J E LindgrenH Gillespie
Dec 8, 1998·Lancet·W Hall, N Solowij
Aug 15, 2000·Drug and Alcohol Dependence·M M AungB R Martin
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A H LichtmanB R Martin
Oct 10, 2002·Psychopharmacology·H Valerie CurranJohn Henry
Jun 1, 2005·Pharmacology, Biochemistry, and Behavior·Thomas Lundqvist
Mar 31, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johannes G RamaekersManfred R Moeller
May 26, 2006·Drug and Alcohol Dependence·J G RamaekersG Kauert
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cécile HenquetJim van Os
Oct 5, 2006·Psychopharmacology·Mohini Ranganathan, Deepak Cyril D'Souza
Jun 3, 2008·Journal of Psychopharmacology·L ZuurmanJ M A van Gerven
Aug 23, 2008·Journal of Psychopharmacology·J G RamaekersM R Moeller
Feb 4, 2009·Journal of Mass Spectrometry : JMS·Volker AuwärterNerea Ferreirós
May 16, 2009·Drug and Alcohol Dependence·Ziva D Cooper, Margaret Haney
Oct 20, 2009·Lancet·Wayne Hall, Louisa Degenhardt
Jan 9, 2010·Schizophrenia Research·Helge MüllerJuan-Manuel Maler
Apr 10, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jörg TeskeHans Dieter Tröger
May 1, 2010·Forensic Science International : Synergy·Tim SobolevskyGrigory Rodchenkov
Feb 15, 2011·Drug and Alcohol Dependence·Susanna Every-Palmer
Jul 12, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Joshua SimmonsCarl Skinner
Mar 16, 2012·Journal of Analytical Toxicology·Kevin G ShanksAndrea R Terrell
May 5, 2012·Addiction·Wendy M BoskerJohannes G Ramaekers
Sep 20, 2012·The Journal of Emergency Medicine·Carson R Harris, Ashley Brown
May 23, 2013·Drug Testing and Analysis·Maren Hermanns-ClausenVolker Auwärter
Oct 1, 2011·The Neurohospitalist·Adam de HavenonPegah Afra
Dec 9, 2014·Forensic Science International : Synergy·Ritva KarinenVigdis Vindenes
May 25, 2015·Psychiatry Research·Dalena van Heugten-Van der KloetJohannes G Ramaekers
Dec 16, 2016·The New England Journal of Medicine·Axel J AdamsRoy Gerona
Apr 4, 2017·Journal of Pharmaceutical and Biomedical Analysis·Stefan W ToennesJohannes G Ramaekers
Nov 23, 2017·British Journal of Pharmacology·Eef L TheunissenJohannes G Ramaekers
Citations
Jul 23, 2020·Frontiers in Psychiatry·Koby CohenAviv Weinstein
Dec 20, 2019·Drug Testing and Analysis·Ryan M Alam, John J Keating
Jan 28, 2021·Psychopharmacology·Eef L TheunissenJohannes G Ramaekers
Jan 27, 2021·Pharmacology, Biochemistry, and Behavior·Eef L TheunissenJohannes G Ramaekers
Mar 4, 2021·Rapid Communications in Mass Spectrometry : RCM·Nam Sook KimSun Young Baek
Nov 7, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hunter RobsonMichael Tatley
May 29, 2021·Nature Reviews. Neuroscience·Johannes G RamaekersEef L Theunissen
Mar 24, 2020·Analytical Chemistry·Annelies CannaertChristophe P Stove