Neurocognition in Kenyan youth at clinical high risk for psychosis.

Schizophrenia Research. Cognition
Daniel MamahDavid M Ndetei

Abstract

Cognitive deficits are typically seen in schizophrenia and in the prodrome, and are a major predictor of functional outcomes in patients. In Africa, few studies have investigated neurocognition in psychosis, which presents a gap in our understanding of the heterogeneity of the illness. In this study, we assessed neurocognition among the largest sample of psychosis-risk participants recruited in the continent to date. The study was conducted in Kenya, and involved 295 psychiatric medication-naïve participants at clinical high-risk (CHR) for psychosis and healthy controls, aged 15-25 yrs. Psychosis-risk status was determined separately using the Structured Interview of Psychosis-Risk Syndromes (i.e. CHR) and by self-report with the Washington Early Recognition Center Affectivity and Psychosis Screen. Eleven tests were administered using the University of Pennsylvania Computerized Neurocognitive Battery. Test performance across groups were investigated, as well as demographic and clinical effects. Fewer participants were designated as being at psychosis-risk with structured interview (n = 47; CHR) than with self-report (n = 155). A MANOVA of cognitive test performance was significant only when groups were ascertained based on self...Continue Reading

References

Dec 1, 1992·Archives of General Psychiatry·S Park, P S Holzman
Jan 1, 1992·Psychological Medicine. Monograph Supplement·A JablenskyA Bertelsen
Jan 1, 1969·Annual Review of Psychology·A F Mirsky
Nov 1, 1994·Acta Psychiatrica Scandinavica·R TharaW W Eaton
Jan 1, 1994·Schizophrenia Bulletin·B A Cornblatt, J G Keilp
Mar 1, 1996·The American Journal of Psychiatry·M F Green
Jun 4, 1998·Acta Psychiatrica Scandinavica·G V MurthyD K Subbakrishna
Jul 11, 2000·Acta Psychiatrica Scandinavica. Supplementum·A Leung, P Chue
Jun 5, 2001·The British Journal of Psychiatry : the Journal of Mental Science·G HarrisonD Wiersma
Apr 12, 2002·Acta Psychiatrica Scandinavica·B N GangadharN Janakiramaiah
Dec 31, 2004·The American Journal of Psychiatry·Elizabeth Cantor-Graae, Jean-Paul Selten
Mar 31, 2005·The American Psychologist·R Walter Heinrichs
May 27, 2005·PLoS Medicine·Sukanta SahaJohn McGrath
Aug 25, 2005·Psychological Medicine·Elizabeth Cantor-GraaeThomas F McNeil
Apr 19, 2007·International Journal of Epidemiology·Michaeline BresnahanEzra Susser
Oct 2, 2007·Schizophrenia Bulletin·Alex CohenOye Gureje
Jan 9, 2008·Archives of General Psychiatry·Tyrone D CannonRobert Heinssen
Feb 15, 2008·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Andreas WittorfStefan Klingberg
Apr 17, 2008·The American Journal of Psychiatry·Kristen A WoodberryLarry J Seidman
Sep 25, 2008·British Medical Bulletin·Katie Marwick, Jeremy Hall
Oct 7, 2008·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Basappa K VenkateshBangalore N Gangadhar
Apr 24, 2009·Schizophrenia Bulletin·Johanna KoskinenJouko Miettunen
Sep 8, 2009·Biological Psychiatry·Anita Riecher-RösslerRolf-Dieter Stieglitz
Oct 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·T K RajjiB H Mulsant
Oct 20, 2009·Journal of Psychiatric Research·P Fusar-PoliUNKNOWN OASIS Team
Jan 6, 2010·The American Journal of Psychiatry·Abraham ReichenbergTerrie E Moffitt
Jul 14, 2010·Neuroscience and Biobehavioral Reviews·Anne-Kathrin J FettLydia Krabbendam
Jul 6, 2011·Early Intervention in Psychiatry·Andrew D ThompsonAlison R Yung
Sep 29, 2011·Comprehensive Psychiatry·Daniel MamahDavid M Ndetei
Jan 14, 2012·Current Pharmaceutical Design·Anthony J GiulianoLarry J Seidman
Mar 7, 2012·Archives of General Psychiatry·Paolo Fusar-PoliPhilip McGuire
Mar 31, 2012·Psychiatry Research·David M NdeteiDaniel Mamah
Jun 6, 2012·Archives of General Psychiatry·Paolo Fusar-PoliStefan Borgwardt
Oct 16, 2012·Child Psychiatry and Human Development·Daniel MamahDavid M Ndetei

❮ Previous
Next ❯

Software Mentioned

SAS
WERCAP
pWERCAP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.