Neurocognitive Changes Associated With Surgical Resection of Left and Right Temporal Lobe Glioma

Neurosurgery
Kyle R NollJeffrey S Wefel

Abstract

Little is known regarding the neurocognitive impact of temporal lobe tumor resection. To clarify subacute surgery-related changes in neurocognitive functioning (NCF) in patients with left (LTL) and right (RTL) temporal lobe glioma. Patients with glioma in the LTL (n = 45) or RTL (n = 19) completed comprehensive pre- and postsurgical neuropsychological assessments. NCF was analyzed with 2-way mixed design repeated-measures analysis of variance, with hemisphere (LTL or RTL) as an independent between-subjects factor and pre- and postoperative NCF as a within-subjects factor. About 60% of patients with LTL glioma and 40% with RTL lesions exhibited significant worsening on at least 1 NCF test. Domains most commonly impacted included verbal memory and executive functioning. Patients with LTL tumor showed greater decline than patients with RTL tumor on verbal memory and confrontation naming tests. Nonetheless, over one-third of patients with RTL lesions also showed verbal memory decline. In patients with temporal lobe glioma, NCF decline in the subacute postoperative period is common. As expected, patients with LTL tumor show more frequent and severe decline than patients with RTL tumor, particularly on verbally mediated measures. How...Continue Reading

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Citations

Mar 24, 2018·Journal of Neurosurgery·Ori BarzilaiZvi Ram
Feb 14, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Milena PertzPatrizia Thoma
Sep 6, 2019·Journal of Neuro-oncology·Matthias SchneiderPatrick Schuss
May 3, 2018·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kyle R NollJeffrey S Wefel
Dec 14, 2019·Neuro-oncology Practice·Eduardo EstevisJeffrey S Wefel
Jan 24, 2020·Journal of Neuro-oncology·Stefanie BetteJens Gempt
Jan 31, 2018·Human Brain Mapping·Eef J HendriksPhilip C De Witt Hamer
Jan 27, 2019·Journal of Neuro-oncology·Kyle R NollJeffrey S Wefel
Jun 30, 2019·Current Treatment Options in Neurology·Kyle R NollJeffrey S Wefel
Jun 2, 2021·American Society of Clinical Oncology Educational Book·Michael W Parsons, Jörg Dietrich

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