Jul 23, 1998

Neurocognitive deficit in schizophrenia: a quantitative review of the evidence

Neuropsychology
R W Heinrichs, K K Zakzanis

Abstract

The neurocognitive literature on test performance in schizophrenia is reviewed quantitatively. The authors report 22 mean effect sizes from 204 studies to index schizophrenia versus control differences in global and selective verbal memory, nonverbal memory, bilateral and unilateral motor performance, visual and auditory attention, general intelligence, spatial ability, executive function, language, and interhemispheric tactile-transfer test performance. Moderate to large raw effect sizes (d > .60) were obtained for all 22 neurocognitive test variables, and none of the associated confidence intervals included zero. The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.

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Mentioned in this Paper

Motor Performance
Memory Loss
Neurologic Manifestations
Schizophrenia
Acquired Language Disorders
Memory for Designs Test
Intelligence
Psychological Inhibition
CD96 gene
CD96

About this Paper

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