Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis

Journal of Psychiatric Research
Wei ZhengYu-Tao Xiang

Abstract

Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as "high quality". Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = -1.00, 95%CI: -1.38, -0.63, P < 0.00001; I2 = 2%), processing speed (SMD = -1.21) and attention/vigilance (SMD = -0.83), and with medium effect size in working memory (SMD = -0.76), reasoning and problem solving (SMD = -0.71), visual (SMD = -0.68) and verbal learning (SMD = -0.67). No significant difference between CHR-P subjects and controls was found regarding social cognition (SMD = -0.33, 95%CI: -0.76...Continue Reading

Citations

May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Michael F GreenJunghee Lee
Mar 14, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Silvana GalderisiAntonio Vita
Oct 18, 2019·European Archives of Psychiatry and Clinical Neuroscience·Sophia KoganDavid Kimhy
Jan 26, 2021·Frontiers in Psychiatry·Penny KaramaounaStella G Giakoumaki
Feb 7, 2021·Schizophrenia Bulletin·Mathilde AntoniadesAndré Schmidt
Feb 20, 2021·European Archives of Psychiatry and Clinical Neuroscience·K Juston Osborne, Vijay A Mittal
May 2, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Kathleen J O'BrienNicole R Karcher
Jun 8, 2021·Schizophrenia Research. Cognition·Daniel MamahDavid M Ndetei
Aug 2, 2021·European Archives of Psychiatry and Clinical Neuroscience·GuiSen WuTianHong Zhang

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