Neurocognitive evaluation of long term survivors of atypical teratoid rhabdoid tumors (ATRT): The Canadian registry experience

Pediatric Blood & Cancer
Lucie Lafay-CousinEric Bouffet

Abstract

Because atypical teratoid rhabdoid tumor(ATRT) is a rare disease of infancy carrying a grim prognosis, focus on long-term outcome, especially neurocognitive remained very limited. With new era of multimodality therapy, an increasing proportion of patients are now long-term survivors. Retrospective review of neuropsychological (NP) status of survivors from the Canadian ATRT registry. Among 77 patients diagnosed between 1995-2012, 16(22%) were survivors. Formal NP assessments were available in eight patients. Partial information on academic achievement was available on three additional patients. There were four girls and seven boys diagnosed at a median age of 27.5 months. Seven patients underwent complete resection and three had metastatic disease. All but one received sequential high dose chemotherapy. Five patients received intrathecal chemotherapy. Three patients underwent radiation. Median age at time of formal NP assessment was 7.6 years (3.9-9.8). Full Scale Intellectual Quotient (FSIQ) ranged from less than 50-119 (mean 78). Simple expressive and receptive language appeared relatively preserved. Three recently diagnosed patients (median time assessment from diagnosis 2.6 years (1.6-4.7)) had average to high average FSIQ, ...Continue Reading

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Citations

Jun 9, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Khaled ElsayadHans Theodor Eich
Feb 9, 2018·Pediatric Blood & Cancer·Karolina NemesUNKNOWN EU-RHAB consortium
Mar 5, 2020·Neuro-oncology·Lindsey M HoffmanAnnie Huang
Dec 14, 2018·Bioengineering·Natasha Pillay Smiley, Soumen Khatua
Oct 7, 2020·Journal of Neuro-oncology·Cody L NesvickDavid J Daniels
Dec 24, 2016·Current Opinion in Supportive and Palliative Care·Amanda D HutchinsonCarlene Wilson
Nov 4, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Meerim ParkChuhl Joo Lyu

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