Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report

Bipolar Disorders
I Nicol FerrierAllan H Young

Abstract

Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with a genetic predisposition to BD would be expected to display the same deficits. This study, therefore, examined neuropsychological function in healthy first-degree relatives of patients with BD. A cross-sectional design was employed to compare the performance of 17 unaffected first-degree relatives of BD patients and 17 demographically matched controls on a range of neuropsychological tests. Relatives were significantly impaired on Backward Digit Span, Spatial Span and on tasks of visuospatial declarative memory in comparison with controls. Psychomotor performance and verbal declarative memory were intact, as were non-working memory aspects of executive performance. The selective deficits in executive control and declarative memory exhibited by relatives in this study have previously been reported in euthymic BD patients suggesting they may be useful endophenotypic markers of genetic vulnerability to BD.

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Nov 1, 1986·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·A BaddeleyH Spinnler
Mar 24, 1999·Biological Psychiatry·M L GourovitchT E Goldberg
Apr 22, 1999·The British Journal of Psychiatry : the Journal of Mental Science·E SigurdssonS Checkley
Jan 25, 2000·The British Journal of Psychiatry : the Journal of Mental Science·I N FerrierJ Scott
Jan 5, 2002·Journal of Experimental Psychology. General·Akira MiyakeMary Hegarty
Apr 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·I Nicol Ferrier, Jill M Thompson
May 25, 2002·Psychological Medicine·J S RubinszteinB J Sahakian
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Feb 4, 2010·Archives of General Psychiatry·David C GlahnMichael A Escamilla
Apr 6, 2007·Der Nervenarzt·I Henseler, Oliver Gruber
Nov 19, 2010·European Archives of Psychiatry and Clinical Neuroscience·Sara Lera-MiguelLuisa Lázaro
Apr 23, 2011·European Archives of Psychiatry and Clinical Neuroscience·Tessa ChristodoulouSophia Frangou
May 3, 2007·Psychological Medicine·Samuel D R StoddartLisa A Jones
Feb 26, 2010·Applied Neuropsychology·Grant L IversonAllan H Young
Oct 24, 2012·Cognitive Neuropsychiatry·Tamsyn E Van Rheenen, Susan L Rossell
Aug 8, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Susanna JuseliusAnnamari Tuulio-Henriksson
May 2, 2008·Schizophrenia Bulletin·S Kristian HillJohn A Sweeney
Apr 17, 2008·Psychiatry and Clinical Neurosciences·Jitendra K TrivediRajul Tandon
Aug 25, 2007·Annual Review of Clinical Psychology·Ellen Leibenluft, Brendan A Rich
Jun 21, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V B DelgadoM L F Chaves
May 9, 2006·Journal of Affective Disorders·Lucy J RobinsonP Brian Moore
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Jonathan SavitzRajkumar Ramesar
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Eugenia KravaritiRobin M Murray
Oct 30, 2013·International Journal of Psychiatry in Clinical Practice·Filiz Civil ArslanEvrim Ozkorumak
Aug 27, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nathalie BesnierJean-Michel Azorin
Apr 27, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·E VietaF Kapczinski
Mar 21, 2012·Journal of Affective Disorders·Claire DabanFrank Bellivier
Dec 4, 2009·Neuroscience and Biobehavioral Reviews·Elena I IvlevaCarol A Tamminga
Oct 6, 2009·Journal of Affective Disorders·Scott A LangeneckerMelvin G McInnis
Aug 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Flávio KapczinskiMichael Berk
Aug 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Guy M GoodwinEduard Vieta
Dec 3, 2015·Annals of General Psychiatry·Eirini Tsitsipa, Konstantinos N Fountoulakis
Jul 25, 2009·Bipolar Disorders·Yih-Lynn HsiaoRu-Band Lu
Jun 23, 2009·Bipolar Disorders·Joseph F Goldberg, K N Roy Chengappa
Aug 8, 2007·Bipolar Disorders·Jill M ThompsonI Nicol Ferrier
Aug 4, 2009·Early Intervention in Psychiatry·Giacomo SalvadoreHusseini K Manji
Dec 17, 2008·Acta Psychiatrica Scandinavica·K JamrozinskiH Scherk
Mar 10, 2009·Bipolar Disorders·Seema QuraishiTimothea Toulopoulou
Nov 9, 2007·Bipolar Disorders·Daniel P DicksteinEllen Leibenluft
Jul 29, 2008·Bipolar Disorders·Suzanne Lucia BarrettDavid John King
Jan 18, 2006·Bipolar Disorders·In Kyoon LyooPerry F Renshaw

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.