Neurocognitive functions and quality of life in haematological patients receiving haematopoietic stem cell grafts: a one-year follow-up pilot study

Journal of Clinical and Experimental Neuropsychology
Helena HarderMartin J van den Bent

Abstract

Longitudinal data of neurocognitive functions and quality of life (QOL) were obtained for a cohort of 25 patients followed before transplant and through the first year after haematopoietic stem cell transplantation (SCT). A battery of neuropsychological tests and two self-report questionnaires were used to assess neurocognitive functions, QOL and psychological functioning. In comparison to normative data, up to one-fourth of the patients experienced impaired functioning on several cognitive domains before SCT. Random regression modelling revealed a slight improvement in the mean group scores of memory tasks over time, especially for younger patients. Impairment in neurocognitive functions was positively related to depression and anger at baseline, and to the emotional functioning scale at follow-up. These preliminary results emphasize the significance of a pre-treatment assessment and the need of a large baseline sample in future longitudinal studies to overcome the expected dropout rate of more than 50%.

References

Nov 1, 1992·Cancer·M A AndrykowskiP J Henslee-Downey
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A MeyersD Przepiorka
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T A AhlesL Mills
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·F WenzM Wannenmacher
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·M PeperM Wannenmacher
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·F WenzM Wannenmacher
Sep 1, 1955·Journal of Abnormal Psychology·J E DOPPELT, W L WALLACE

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Citations

Sep 22, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Melissa A FriedmanChristina A Meyers
Jul 15, 2015·Brain Imaging and Behavior·D D CorreaN Relkin
Sep 24, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Samantha J MayoJeffrey H Lipton
Jun 25, 2009·Cancer·Grace ChangJoseph H Antin
Jan 31, 2021·Pilot and Feasibility Studies·Samantha J MayoJohn Kuruvilla
Aug 12, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Aasha I HooglandHeather S L Jim

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Methods Mentioned

BETA
MDS

Software Mentioned

SAS System
Statistical Package for Social Sciences ( SPSS )

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