Neurocognitive outcomes after pediatric adenotonsillectomy for obstructive sleep apnea: A systematic review and meta-analysis

International Journal of Pediatric Otorhinolaryngology
Sungjin A SongMacario Camacho

Abstract

To provide an up-to-date systematic review and critical appraisal of prospectively performed studies evaluating neurocognitive function in children treated with adenotonsillectomy. PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library. Searches were performed from inception through September 2, 2015. Nineteen prospective studies (898 adenotonsillectomy patients) met criteria and reported neurocognitive outcomes. The average age of children was 6.6±2.3 years (range 2.5-14 years) and 51.1% were male. Pre- and post-operative data utilizing the Neuropsychological Developmental Assessment score demonstrated an increase from a means±standard deviations of 101.5±14.7 [95% CI 100.0, 103.0] to 108.8±13.4 [95% CI 107.4, 110.2], p-value <0.0001 (375 children, three studies). Pre- and post-operative data utilizing the Stanford-Binet Intelligence Scales (IQ) demonstrated an increase in IQ scores from a means±standard deviations of 97.1±13.8 [95% CI 91.6, 95.4] to 100.7±11.1 [95% CI 100.4, 103.4], p-value <0.0001 (254 children, three studies). The mean pre- and post-adenotonsillectomy apnea-hypopnea index (AHI) decreased from 8.0 to 1.8 (274 children, six studies). This meta-analysis found an improvement in neurocognitive function...Continue Reading

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Citations

Feb 22, 2018·The Journal of Laryngology and Otology·L PablaK Blackmore
Sep 15, 2020·International Journal of Pediatric Otorhinolaryngology·Mary Frances MussoEllen M Friedman
Dec 8, 2021·The Annals of Otology, Rhinology, and Laryngology·Derek WuNira A Goldstein
Jan 11, 2020·Pediatrics·Karen A WatersKurt Lushington

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